Sodium bicarbonate (baking soda) trials recruiting now
22 registrations that name sodium bicarbonate as a study arm and are recruiting or about to, as ClinicalTrials.gov listed them on Oct 20, 2026. Read each listing for its full criteria and current status.
Kymata never assesses eligibility. Each listing names its own criteria; only its study team can say whether someone can join. Trial doses are given under the trial's monitoring and are not a schedule for anyone outside it.
Filter 22 registrations
Status
Phase
13US sites across 7 states
1
2 to 4
5 to 19
20 or more
All 22 registrations
RecruitingNCT05928936
Neurovascular Regulation During Exercise in Humans With Chronic Kidney Disease: Sympatholysis in CKD
Phase 2
Emory University
About 156 people
Started Nov 11, 2022
In plain words A Phase 2 study of sodium bicarbonate in people 40 to 75, run by Emory University. It plans to enroll about 156 people at 2 US sites.
Who it lists and where
Who the trial lists, as registered
Lists people 40 to 75. Conditions: Chronic Kidney Disease.
patients with CKD (Stages III and IV), kidney transplant recipients with varying degrees of kidney function, or persons without kidney disease as matched study controls
sedentary and do not regularly exercise (defined as exercising < 20 minutes twice per week)
CKD patients must have stable renal function (no greater than a decline of estimated glomerular filtration (eGFR) of 1 cc/min/1.73 m2 per month over the prior 6 months) and baseline serum bicarbonate 22-24 mmol/L
comorbid hypertension
The exclusion criteria are on the listing.
What it tests, as registered
Sodium Bicarbonate; Exercise Training; Placebo
Registered summary
The goals of this project are to investigate the mechanisms and potential therapies related to exercise capacity in persons with chronic kidney disease (CKD).
Where, as registered
2 US sites in 1 state.
RecruitingNCT04984226
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
Phase 2
University of California, Davis
About 80 people
Started Sep 8, 2023
In plain words A Phase 2 study of sodium bicarbonate in people 21 to 85, run by University of California, Davis. It plans to enroll about 80 people at 2 US sites.
Who it lists and where
Who the trial lists, as registered
Lists people 21 to 85. Conditions: Chronic Kidney Diseases; Metabolic Acidosis; Fatigue; Physical Endurance; Insulin Resistance; Mitochondrial Energetics; Diabetes.
Moderate-severe CKD determined by eGFR <50ml/min per 1.73m2 by CKD EPI equation on at least 2 consecutive occasions.
Metabolic acidosis defined as bicarbonate level<24 on two consecutive occasions. Bicarbonate level of 24 or less allowed if eGFR<=45ml/min per 1.73m2
Age 21 to 85 years old
The exclusion criteria are on the listing.
What it tests, as registered
Sodium bicarbonate; placebo
Registered summary
Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in vivo tools to study the pathophysiology of poor physical endurance in a clinical trial treating metabolic acidosis among persons living with chronic kidney disease.
Where, as registered
2 US sites in 2 states.
RecruitingNCT07424625
A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients
Phase 4
Mayo Clinic
About 250 people
Started Sep 14, 2026
In plain words A Phase 4 study of sodium bicarbonate in people 21 and older, run by Mayo Clinic. It plans to enroll about 250 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 21 and older. Conditions: Metabolic Acidosis.
Cardiothoracic surgery with use of cardiopulmonary bypass
Presence of metabolic acidosis (defined as a base excess of <-5)
The purpose of this research is to determine if two commonly used medications to treat metabolic acidosis in the setting of cardiac surgery, sodium bicarbonate and THAM, are equivalent.
Where, as registered
1 US site in 1 state.
RecruitingNCT05005793
Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients
Phase 4
University of Colorado, Denver
About 120 people
Started Dec 1, 2021
In plain words A Phase 4 study of sodium bicarbonate in people 18 to 80, run by University of Colorado, Denver. It plans to enroll about 120 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 80. Conditions: Metabolic Acidosis; Kidney Transplant; Complications; Vascular Diseases.
Age 18-80 years
Serum bicarbonate 16-24 mEq/L on 2 separate measurements (at least 1 day apart)
Kidney transplant received 1 year prior to randomization
eGFR ≥ 45 ml/min/1.73m2 by CKD-EPI equation
7 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Sodium bicarbonate; Placebo
Registered summary
Lower serum bicarbonate levels, even within the normal laboratory range, in kidney transplant recipients (KTRs) are associated with an increased risk of graft loss, cardiovascular events and mortality. Because acid retention is common in KTRs, it is plausible that alkali therapy in KTRs may also result in improved vascular and graft function. The investigators will perform a randomized, double-blinded, placebo-controlled, 12 month study in 120 KTRs to examine the effect of sodium bicarbonate therapy on surrogate markers of CVD and graft function. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT02411773
Sympatholysis in Chronic Kidney Disease
Phase 1
Emory University
About 110 people
Started Jun 11, 2015
In plain words A Phase 1 study of sodium bicarbonate in people 18 to 75, run by Emory University. It plans to enroll about 110 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 75; healthy volunteers accepted. Conditions: Chronic Kidney Disease.
Veterans with Stages III and IV Chronic Kidney Disease (CKD)
Kidney transplant recipients with varying degrees of kidney function
Veterans 18-75 years old, without kidney disease, as study controls
Exercise less than 20 minutes twice per week
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
Sodium Bicarbonate; Placebo; Exercise Training; Control to Exercise (Stretching)
Registered summary
The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate).
Where, as registered
1 US site in 1 state.
RecruitingNCT06335537
Impact of Sodium Bicarbonate on 24-hour Urine Parameters in Hypocitriuric and Uric Acid Stone Formers
Phase 1
University of California, Irvine
About 100 people
Started May 1, 2025
In plain words A Phase 1 study of sodium bicarbonate in people 18 to 80, run by University of California, Irvine. It plans to enroll about 100 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 80. Conditions: Uric Acid Stones.
> 18 years of age and < 80 years of age,
Hypocitriuric (<320 mg/24 hours), Calcium Oxalate Stone or Uric Acid stone formers, currently on Urocit-K therapy as the standard of care.
The exclusion criteria are on the listing.
What it tests, as registered
Potassium citrate; Sodium bicarbonate
Registered summary
The incidence of kidney stone disease continues to rise globally. Although the treatment of kidney stone disease has dramatically improved in recent years, surgical management remains invasive and expensive. Patients who develop kidney stones are at high risk of recurrence during their lifetime; therefore, prevention of stones should be a primary focus. Low levels of citrate and acidic urine are risk factors for the formation of kidney stones such as calcium oxalate and uric acid, respectively. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT05719467
SAINT: Safe Induction of Labor Trial
Phase 3
Oslo University Hospital
About 3,000 people
Started Jan 3, 2023
In plain words A Phase 3 study of sodium bicarbonate in female participants 18 to 50, run by Oslo University Hospital. It plans to enroll about 3,000 people at 5 sites, none in the US.
Over the past years, the rates of labor induction have increased steadily, and at present more than one in four births occurs after induced labor in Norway. There is evidence that several groups of women benefit from labor induction, including those with preeclampsia (1), postdate pregnancy, diabetes, a large-for-gestational-age fetus, gestational diabetes, prelabor rupture of membranes at term, preterm prelabor rupture of membranes, twin pregnancy and intrahepatic cholestasis of pregnancy. The full summary is on the listing.
Where, as registered
No US site; Norway (5).
RecruitingNCT06966635
Exploratory Study on the Treatment of Gout With Potassium Citrate Sustained-release Tablets
Phase 4
Huashan Hospital
About 312 people
Started Apr 10, 2024
In plain words A Phase 4 study of sodium bicarbonate in people 18 to 70, run by Huashan Hospital. It plans to enroll about 312 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 70. Conditions: Hyperuricemia or Gout; Nephrolithiasis.
Meet the diagnostic criteria of the American College of Rheumatology (ACR) and the European League against Rheumatism (EULAR) for gout in 2015
Age 18-70 years old, gender is not limited
The interval between the most recent acute onset of gout is at least > 2 weeks
Routine treatment with stable dose of uric-lowering drugs for > 4 weeks
3 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Sodium Bicarbonate Oral Capsule; Potassium Citrate Tablets; uric-acid-lowering drug
Registered summary
To evaluate whether alkalization has the effect of lowering uric acid and reducing gout flare and determine whether alkalization has a role in the prevention and treatment of urinary calculi in gout, the research participants were divided into the control group, the potassium citrate group and the sodium bicarbonate group. 2 alkalization groups took potassium citrate three times a day 2.16g each time, or sodium bicarbonate three times a day, 1.0g each time, on the basis of the standard uric acid-lowering treatment plan. The full summary is on the listing.
Where, as registered
No US site; China (1).
RecruitingNCT06734481
Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural Effusion
No phase
First Affiliated Hospital of Ningbo University
About 260 people
Started Apr 1, 2024
In plain words A study of sodium bicarbonate in people 18 to 80, run by First Affiliated Hospital of Ningbo University. It plans to enroll about 260 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 80. Conditions: Complicated Pleural Effusion/ Empyema.
Hospitalized patients aged 18 to 80 years, inclusive.
Patients fulfilling any one of the following three criteria for complicated pleural effusion: A. Pleural fluid pH < 7.2; B. Pleural fluid glucose < 2.2 mmol/L and LDH > 1000 IU/L; C. Positive pleural fluid culture or smear for pathogens.
Pleural effusion volume exceeding 300 mL, as determined by CT imaging using the formula D\^2 * L (where D represents the maximum depth and L the maximum length), and for whom pleural effusion drainage is clinically indicated according to…
The goal of this clinical trial is to evaluate the safety and efficacy of sodium bicarbonate pleural lavage in treating complex pleural effusion in adult. The main questions it aims to answer are: Will sodium bicarbonate pleural lavage reduce the failure rate of medical treatment (referral rate for surgery) for complicated pleural effusion？ Can sodium bicarbonate pleural lavage accelerating the rehabilitation of patients with complicated pleural effusion？ Will sodium bicarbonate pleural lavage improve the prognosis of patients with complicated pleural effusion? Participants will will undergo… The full summary is on the listing.
Where, as registered
No US site; China (1).
RecruitingNCT05830136
Application of Sodium Bicarbonate Ringer's Solution in Laparoscopic Hepatectomy
No phase
The First Affiliated Hospital with Nanjing Medical University
About 100 people
Started Feb 1, 2022
In plain words A study of sodium bicarbonate in people 18 and older, run by The First Affiliated Hospital with Nanjing Medical University. It plans to enroll about 100 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Hepatic Ischemia.
≥18 years old,
patients who plan to undergoing laparoscopic hepatectomy ;
Willing to sign informed consent.
The exclusion criteria are on the listing.
What it tests, as registered
sodium bicarbonate Ringer's solution
Registered summary
Compared the effects of Sodium bicarbonate Ringer's solution and lactate Ringer's solution on the internal environment and hemodynamics of patients during laparoscopic liver resection, to observe the application prospect of sodium bicarbonate Ringer's solution in Laparoscopic hepatectomy.
Where, as registered
No US site; China (1).
RecruitingNCT07730606
Acute Sodium Bicarbonate Supplementation in Female Basketball Players
Phase 3
Krzysztof Durkalec-Michalski
About 100 people
Started Mar 1, 2026
In plain words A Phase 3 study of sodium bicarbonate in female participants 16 to 35, run by Krzysztof Durkalec-Michalski. It plans to enroll about 100 people at 1 site, none in the US.
5 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Sodium Bicarbonate (NaHCO3); Placebo
Registered summary
This randomized, double-blind, placebo-controlled crossover study aims to evaluate the effect of acute sodium bicarbonate supplementation, compared with placebo, on physical capacity and blood biochemical marker concentrations in highly trained female basketball players.
Where, as registered
No US site; Poland (1).
RecruitingNCT06525402
Effect of Sodium Bicarbonate, Saline and Black Mulberry Syrup on Degree of Oral Mucositis in Children Receiving Chemotherapy
No phase
Burdur Mehmet Akif Ersoy University
About 54 people
Started Jan 30, 2025
In plain words A study of sodium bicarbonate in people 6 to 18, run by Burdur Mehmet Akif Ersoy University. It plans to enroll about 54 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 6 to 18. Conditions: Oral Mucositis; Chemotherapy Effect.
The willingness of the family and the child to participate in the study
Parent and child have separately informed written consent form
Be between 6-18 years old
Receiving chemotherapy and being hospitalized for chemotherapy treatment
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
Sodium Bicarbonate Group (Usual care); Saline Group; Black Mulberry Syrup Group
Registered summary
This study was planned as a randomized controlled experimental study in order to compare the effects of oral care with saline and black mulberry syrup in addition to sodium bicarbonate on oral mucositis level in children aged 6-18 years receiving chemotherapy.
Where, as registered
No US site; Turkey (Türkiye) (1).
RecruitingNCT07135934
Effects of Single Sodium Bicarbonate Supplementation on National-Level Finswimming Performance
No phase
Palacky University
About 20 people
Started Jul 1, 2025
In plain words A study of sodium bicarbonate in people 15 to 30, run by Palacky University. It plans to enroll about 20 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 15 to 30; healthy volunteers accepted. Conditions: Sport Performance; Acid Base Imbalance; Ergogenic Support; Sodium Bicarbonate; Water Sports; Biomechanics.
Member of a wider national selection in finswimming (junior or senior level)
Regular participation in competitive finswimming training (≥4 sessions per week)
Age between 15 and 30 years
Absence of chronic illness or injury
2 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Sodium Bicarbonate (NaHCO3); Placebo
Registered summary
This randomized, double-blind, placebo-controlled crossover trial will investigate the acute effects of sodium bicarbonate supplementation on performance, stroke biomechanics, and selected physiological and perceptual responses during a simulated 200-meter Bi-Fins race in elite finswimmers.
Where, as registered
No US site; Czechia (1).
RecruitingNCT06826222
Sodium Bicarbonate Intake on Endurance Performance
No phase
Hacettepe University
About 19 people
Started Nov 3, 2024
In plain words A study of sodium bicarbonate in female participants 18 to 40, run by Hacettepe University. It plans to enroll about 19 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists female participants 18 to 40; healthy volunteers accepted. Conditions: The Effects of Sodium Bicarbonate Supplementation on Endurance Performance in Recreational Female Runners.
Female, aged 18-40.
Recreational runner with a minimum one-year history of regular training (at least three days per week).
Experience in races of 10 km or more (verified by an official race result).
Ability to complete a 10 km distance at an average pace below 6.00 min/km (confirmed through best-record evidence via applications like Strava).
The exclusion criteria are on the listing.
What it tests, as registered
Sodium Bicarbonate (NaHCO3); Sodium Chloride
Registered summary
Sodium bicarbonate (SB) is one of the ergogenic aids that enhance short-duration, high-intensity sports performance by improving the buffering system. However, studies suggest that SB may also be beneficial for prolonged high-intensity endurance exercises, where anaerobic glycolysis plays a role. The commonly used SB dose in these studies (0.3 g/kg) often leads to gastrointestinal (GI) discomfort, necessitating alternative approaches. Among various protocols, consuming SB with a carbohydrate-rich meal has been identified as an effective strategy to mitigate GI distress. The full summary is on the listing.
Where, as registered
No US site; Turkey (Türkiye) (1).
Not yet recruitingNCT07408076
Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones
Phase 1 and 2
University of California, Los Angeles
About 30 people
Starts Feb 1, 2026 (estimated)
In plain words A Phase 1 and 2 study of sodium bicarbonate in people 18 and older, run by University of California, Los Angeles. It plans to enroll about 30 people at 6 sites, 4 of them in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Kidney Stones, Urolithiasis, Hypocitraturia; Nephrolithiasis.
Adult >18 years of age
History of nephrolithiasis
One 24h urine collections within one year of enrollment with hypocitraturia.
Patients currently utilizing or considering use of Kcit for stone prevention
The exclusion criteria are on the listing.
What it tests, as registered
Potassium Citrate; Sodium Bicarbonate
Registered summary
Kidney stones affect 1 in every 11 people in the US each year. In patients with kidney stones who are prescribed medications for stone management, only 30.2% are adherent to a medication regime and even fewer, only 13.4 % are adherent with citrate medications. Prescription potassium citrate can be expensive for many patients, leading to non-compliance. Sodium bicarbonate is a potential medication alternative that is cheaper and can potentially alkalinize the urine and/or decrease the risk of future kidney stones. The full summary is on the listing.
Where, as registered
4 US sites in 2 states; also Canada (1), Iceland (1).
Not yet recruitingNCT04651088
Comparing Alkalinizing Agents Efficacy on Stone Risk in Patients on a Metabolically Controlled Diet
Early phase 1
University of Texas Southwestern Medical Center
About 15 people
Starts Jul 1, 2026 (estimated)
In plain words An early phase 1 study of sodium bicarbonate in people 18 to 90, run by University of Texas Southwestern Medical Center. It plans to enroll about 15 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 90; healthy volunteers accepted. Conditions: Kidney Stone.
The purpose of this study is to compare over the counter and alternative prescription urinary alkalinizing agents to slow release potassium citrate in their ability to modify urinary parameters associated with stone formation.
Where, as registered
1 US site in 1 state.
Not yet recruitingNCT07321379
Efficacy of Bicarbonate on the Risk of Assisted Delivery in Nulliparous Women With Prolonged Labour
No phase
Copenhagen University Hospital, Hvidovre
About 1,520 people
Starts Feb 1, 2026 (estimated)
In plain words A study of sodium bicarbonate in female participants 18 to 50, run by Copenhagen University Hospital, Hvidovre. It plans to enroll about 1,520 people at 3 sites, none in the US.
Gestational age ≥34+0 - <42+0 (days +weeks) at onset of labour.
4 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Sodium bicarbonate; Placebo
Registered summary
The goal of this clinical trial is to learn if oral bicarbonate can treat prolonged labour in nulliparous women with prolonged labour. The main question it aims to answer is: Do oral bicarbonate and restrictive oxytocin use reduce assisted delivery rate (emergency cesarean and vacuum/forceps delivery) in nulliparous women with prolonged labour. Researchers will compare bicarbonate and placebo (a look-alike substance that contains no drug) to see if bicarbonate works to treat prolonged labour. The full summary is on the listing.
Where, as registered
No US site; Denmark (3).
Not yet recruitingNCT06249061
Oral Sodium Bicarbonate for the Prevention of Labour Dystocia
No phase
Liz Darling
About 200 people
Starts Dec 2025 (estimated)
In plain words A study of sodium bicarbonate in female participants of any age, run by Liz Darling. It plans to enroll about 200 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists female participants of any age; healthy volunteers accepted. Conditions: Labour Dystocia.
Pregnant,
Nulliparous,
Cephalic presenting,
Live, singleton fetus,
4 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
oral sodium bicarbonate
Registered summary
Sodium bicarbonate is often used by athletes to improve their muscle's ability to contract and power their activity. It works by decreasing the risk of lactic acid build-up, which causes cramping and fatigue. Some research suggests that using sodium bicarbonate in labour could help to improve the ability of the uterus to contract, helping to prevent labour dystocia (stalled or slow progress in labour). This could ultimately increase the chance of spontaneous vaginal delivery. The full summary is on the listing.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07734740
Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes
Phase 3
Prince of Wales Hospital, Shatin, Hong Kong
About 80 people
Starts Aug 2026 (estimated)
In plain words A Phase 3 study of sodium bicarbonate in people 18 and older, run by Prince of Wales Hospital, Shatin, Hong Kong. It plans to enroll about 80 people at 3 sites, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Dermatochalasis of Upper Eyelid; Blepharoplasty.
Patients undergoing bilateral upper eyelid blepharoplasty requiring subcutaneous anaesthesia at Prince of Wales Hospital, Alice Ho Miu Ling Nethersole Hospital and CUHK Medical Centre; and
The goal of this clinical trial is to determine whether buffering, warming, or addition of hyaluronidase or tranexamic acid to lignocaine during eyelid injection of local anaesthesia reduce injection pain and procedure-related pain and improve perioperative haemostasis.
Where, as registered
No US site; Hong Kong (3).
Not yet recruitingNCT07231900
Sodium Bicarbonate in Intra-dialytic Hypertension in Chronic Hemodialysis Patients
Phase 2 and 3
Assaf-Harofeh Medical Center
About 40 people
Starts Nov 10, 2025 (estimated)
In plain words A Phase 2 and 3 study of sodium bicarbonate in people 18 and older, run by Assaf-Harofeh Medical Center. It plans to enroll about 40 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Hypertension in Dialysis Patients.
Chronic hemodialysis patient > 3 months
3 dialysis per week, KTV>1.2
capable of informed concent.
rise in blood pressure during hemodialysis > 10 mm Hg, for at least 50% of dialysis sessions in the month prior to inclusion.
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
Sodium Bicarbonate (NaHCO3); Placebo
Registered summary
The study is designed to diminish intra-dialytic hypertension in chrnic hemodialysis patients suffering from metabolic acidosis (low bicarbonate levels). The intervention is a tab of 500 mg sodium bicarbonate twice a day for one month, vs. placebo.
Where, as registered
No US site; Israel (1).
Not yet recruitingNCT07688434
Pilot Trial of Oral Sodium Bicarbonate Versus Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic Acidosis
No phase
University of Sfax
About 37 people
Starts Jul 2026 (estimated)
In plain words A study of sodium bicarbonate in people 18 and older, run by University of Sfax. It plans to enroll about 37 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: End-stage Renal Disease (ESRD); Chronic Hemodialysis; Metabolic Acidosis.
Age ≥ 18 years.
Chronic hemodialysis for at least 3 months.
Stable hemodialysis prescription: 3 times a week, high-flux dialyzers, no major change in dialysis prescription in the previous weeks.
Predialysis low "alkaline reserves" (serum bicarbonate concentration) according to the operational threshold used in the unit (e.g., "alkaline reserves" < 22 mmol/L), consistent with KDIGO 2017 definition of metabolic acidosis.
6 more inclusion criteria and the exclusion criteria are on the listing.
Metabolic acidosis is frequent in chronic hemodialysis patients and is associated with adverse clinical outcomes. Two commonly used strategies to correct acidosis are oral sodium bicarbonate supplementation and increasing the bicarbonate concentration of the dialysate, but their comparative effectiveness and tolerance in routine care remain uncertain. The full summary is on the listing.
Where, as registered
No US site; Tunisia (1).
Not yet recruitingNCT07519408
Acute Kidney Injury and Ultra-endurance Running
No phase
Arizona State University
About 30 people
Starts Jun 27, 2026 (estimated)
In plain words A study of sodium bicarbonate in people 18 to 50, run by Arizona State University. It plans to enroll about 30 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 50; healthy volunteers accepted. Conditions: AKI (Acute Kidney Injury) Due to Trauma.
Running in the Western States Endurance Run in either 2026, 2027 or 2028
No contraindications to exercise as indicated by the Physical Activity Readiness Questionnaire (PAR-Q+) as prepared by the American College of Sports Medicine (ACSM)
Not currently taking medicine or experiencing illness that may influence the cardiovascular or neuromuscular system
Age ≥18 and ≤ 50 years old and injury free (skeletal muscle) for > 3 months
The exclusion criteria are on the listing.
What it tests, as registered
Sodium Bicarbonate (NaHCO3); Placebo
Registered summary
This study aims to understand how participating in the Western States Endurance Run (WSER), a 100-mile ultramarathon, affects kidney health. Long, strenuous exercise in hot conditions can temporarily strain the kidneys, especially when combined with dehydration, muscle breakdown, and the use of common pain-relief medications such as ibuprofen. Although kidney stress has been reported in endurance sports, no study has examined it directly in runners during the WSER using newer, more sensitive urine markers of kidney injury. The full summary is on the listing.
Where, as registered
No sites listed yet.
ClinicalTrials.gov lists 58 open registrations for this search, including ones where sodium bicarbonate is not a study arm or that are past the 22 we keep. Search them on ClinicalTrials.gov (opens in new tab).