Glutamate (MSG, monosodium glutamate) trials recruiting now

2 registrations that name glutamate as a study arm and are recruiting or about to, as ClinicalTrials.gov listed them on Oct 20, 2026. Read each listing for its full criteria and current status.

Kymata never assesses eligibility. Each listing names its own criteria; only its study team can say whether someone can join. Trial doses are given under the trial's monitoring and are not a schedule for anyone outside it.

Filter 2 registrations

Status

1US sites across 1 state

All 2 registrations

RecruitingNCT02902198

Taste Physiology in Obese Volunteers Before and After Bariatric Surgery

  • No phase
  • University Hospital, Basel, Switzerland
  • About 16 people
  • Started Dec 2014

In plain words A study of glutamate in people 18 to 55, run by University Hospital, Basel, Switzerland. It plans to enroll about 16 people at 1 site, none in the US.

Who it lists and where

Who the trial lists, as registered

Lists people 18 to 55. Conditions: Obesity.

  • morbidly obese patients (BMI min 35kg/m2) scheduled for bariatric surgery
  • right handed

The exclusion criteria are on the listing.

What it tests, as registered

Placebo; Glucose; Monosodium glutamate; Quinine

Registered summary

The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.

Where, as registered

No US site; Switzerland (1).

Not yet recruitingNCT07700368

Effect of Monosodium Glutamate on Microbiome-Derived Imidazole Propionate Production in Healthy Volunteers

  • No phase
  • University of Chicago
  • About 18 people
  • Starts Jul 15, 2026 (estimated)

In plain words A study of glutamate in people 18 and older, run by University of Chicago. It plans to enroll about 18 people at 1 US site.

Who it lists and where

Who the trial lists, as registered

Lists people 18 and older; healthy volunteers accepted. Conditions: Healthy Adult.

  • Age 18 years or older
  • No antibiotic use in the previous 3 months

The exclusion criteria are on the listing.

What it tests, as registered

L-histidine; Monosodium glutamate (MSG); Sodium chloride (NaCl)

Registered summary

The goal of this clinical trial is to learn whether dietary monosodium glutamate (MSG), a common food flavor enhancer, increases the blood level of a gut-microbiome-derived compound called imidazole propionate (ImP) in healthy adult volunteers. ImP is a compound made by gut bacteria from the amino acid histidine, and higher blood levels have been linked to problems with blood-sugar control. The full summary is on the listing.

Where, as registered

1 US site in 1 state.

ClinicalTrials.gov lists 274 open registrations for this search, including ones where glutamate is not a study arm or that are past the 2 we keep. Search them on ClinicalTrials.gov (opens in new tab).

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