9 registrations that name molecular Hydrogen as a study arm and are recruiting or about to, as ClinicalTrials.gov listed them on Oct 20, 2026. Read each listing for its full criteria and current status.
Kymata never assesses eligibility. Each listing names its own criteria; only its study team can say whether someone can join. Trial doses are given under the trial's monitoring and are not a schedule for anyone outside it.
Filter 9 registrations
Status
2US sites across 1 state
1
2 to 4
5 to 19
20 or more
All 9 registrations
RecruitingNCT07753122
Controlled Trial of Hydrogen Water as a Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
No phase
Fred Friedberg
About 80 people
Starts Aug 15, 2026 (estimated)
In plain words A study of molecular Hydrogen in people 18 to 65, run by Fred Friedberg. It plans to enroll about 80 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 65. Conditions: Chronic Fatigue Syndrome (CFS).
Patients aged 18-65 of both sexes
considered physically capable and willing to perform the study tasks
Meet validated phone-screen eligibility for ME/CFS criteria
Participant has internet and computer
The exclusion criteria are on the listing.
What it tests, as registered
Placebo condition; Molecular hydrogen produced by a metallic magnesium tablet, consumed 3x a day dissolved in water. Treatment duration is 16 weeks.
Registered summary
This is a 16-week controlled treatment trial of an over-the -counter supplement, hydrogen water, for individuals with ME/CFS patients. An active treatment condition will be compared to a placebo-control condition. The study will also seek confirmation of heart rate variability (HRV) as a biomarker, that is, as a predictor of improvement vs. non-improvement to be assessed at treatment termination. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT07009691
Hydrogen Water Intervention With Heart Rate Variability as an Outcome Biomarker in ME/CFS
No phase
Stony Brook University
About 50 people
Starts Jun 9, 2025 (estimated)
In plain words A study of molecular Hydrogen in people 18 to 65, run by Stony Brook University. It plans to enroll about 50 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 65. Conditions: Chronic Fatigue Syndrome.
What it tests, as registered
Hydrogen water which is prepared from an OTC supplement.
Registered summary
The goal of this clinical trial is to learn if the OTC supplement, hydrogen water, works to treat the fatigue-related symptoms and functional limitations in adults with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). It will also examine if heart rate variability (HRV) can be used to predict who will benefit from the hydrogen water treatment. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT07714057
Effect of Hydrogen-rich Water During Tapering on Recovery After Functional Overreaching in Basketball Players
No phase
Palacky University
About 30 people
Started Jul 27, 2026
In plain words A study of molecular Hydrogen in male participants 18 to 35, run by Palacky University. It plans to enroll about 30 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists male participants 18 to 35; healthy volunteers accepted. Conditions: Healthy Active Athletes.
Competitive male basketball players.
Signed informed consent.
Completion of entry medical and laboratory screening.
The exclusion criteria are on the listing.
What it tests, as registered
Hydrogen-rich water; Placebo water
Registered summary
The goal of this clinical trial is to evaluate whether hydrogen-rich water supplementation during tapering improves recovery after functional overreaching in competitive male basketball players aged 18-35 years. The main questions it aims to answer are: * Does hydrogen-rich water improve autonomic recovery after functional overreaching? * Does hydrogen-rich water improve recovery in biochemical, performance, and subjective feeling outcomes during tapering? Researchers will compare hydrogen-rich water to placebo (water containing no molecular hydrogen) to determine whether molecular hydrogen… The full summary is on the listing.
Where, as registered
No US site; Czechia (1).
RecruitingNCT07644000
Effect of Pre-exercise Inhalation of Molecular Hydrogen on Metabolic Response During Graded Exercise in Healthy Women
No phase
Palacky University
About 22 people
Started Jun 22, 2026
In plain words A study of molecular Hydrogen in female participants 18 to 30, run by Palacky University. It plans to enroll about 22 people at 1 site, none in the US.
Regular menstrual cycle with exercise testing scheduled outside the menstrual phase.
Signed informed consent.
The exclusion criteria are on the listing.
What it tests, as registered
Molecular hydrogen; Placebo
Registered summary
The goal of this clinical trial is to evaluate if molecular hydrogen can reduce the metabolic response during graded exercise in healthy women aged 18-30 years. The main questions it aims to answer are: * Does molecular hydrogen reduce the respiratory exchange ratio? * Does molecular hydrogen reduce oxygen uptake? Researchers will compare molecular hydrogen to a placebo (ambient air containing no molecular hydrogen) to see if molecular hydrogen reduces the metabolic response. Participants will: * Inhale molecular hydrogen for 60 minutes each day for 7 days. The full summary is on the listing.
Where, as registered
No US site; Czechia (1).
Not yet recruitingNCT07410065
Supersaturated Hydrogen-Rich Water for Outpatients With Persistent Excess Weight
No phase
Center for Health Sciences, Serbia
About 120 people
Starts Apr 15, 2026 (estimated)
In plain words A study of molecular Hydrogen in people 18 and older, run by Center for Health Sciences, Serbia. It plans to enroll about 120 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older; healthy volunteers accepted. Conditions: Overweight.
Age > 18 years
Body mass index > 25.0 kg/m2 (persisted for at least six months before screening)
Stable on their therapy (if any) for ≥ 3 months
Free of acute disorders and severe chronic diseases
2 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Hydrogen-rich water; Control
Registered summary
The Supersaturated Hydrogen-Rich Water for Outpatients with Persistent Excess Weight (HOPE) study is a Phase III, multicenter, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of daily consumption of supersaturated hydrogen-rich water in adults with persistent excess body weight. The trial investigates whether sustained exposure to molecular hydrogen can favorably influence body composition and key metabolic outcomes compared with a placebo water lacking dissolved hydrogen. The full summary is on the listing.
Where, as registered
No US site; Serbia (1).
Not yet recruitingNCT07865000
The Effect of Hydrogen-Rich Water on Dysmenorrhea and Menstrual Symptom Severity
No phase
Menekşe Nazlı AKER
About 48 people
Starts Oct 14, 2026 (estimated)
In plain words A study of molecular Hydrogen in female participants 18 and older, run by Menekşe Nazlı AKER. It plans to enroll about 48 people and lists no sites yet.
Having regular menstrual cycles occurring every 21-35 days, with bleeding lasting 2-7 days,
Having severe dysmenorrhea according to the WaLIDD score (8-12 points),
Having primary dysmenorrhea,
Being older than 18 years.
The exclusion criteria are on the listing.
What it tests, as registered
Hydrogen-rich water consumption; Drinking water consumption
Registered summary
The study will include hydrogen-rich water and control groups. Young women with severe primary dysmenorrhea will be recruited from Ankara University. Eligible women will be informed about the study, and written informed consent will be obtained. Participants will be assigned to the study groups using block randomization.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07306546
Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral Cancer
No phase
Kaohsiung Medical University Chung-Ho Memorial Hospital
About 36 people
Starts Jan 2026 (estimated)
In plain words A study of molecular Hydrogen in people 18 and older, run by Kaohsiung Medical University Chung-Ho Memorial Hospital. It plans to enroll about 36 people and lists no sites yet.
Diagnosed with oral cancer and receiving microsurgical free flap reconstruction.
Age 18 years or older.
Conscious and able to follow study instructions.
Able to communicate without difficulty in Mandarin, Taiwanese, or through written communication.
The exclusion criteria are on the listing.
What it tests, as registered
Hydrogen Water Oral Care; Water Oral Care
Registered summary
This study employs a Randomized Controlled Trial (RCT) design. Patients diagnosed with oral cancer by the attending physician and who meet the inclusion criteria will be admitted to the study after receiving a full explanation of the study objectives, intervention methods, potential risks, and participant rights from the research team upon their stable transfer to the plastic surgery ward post-operation. Written consent will be obtained from the patient and/or their legally authorized representative after adequate informed consent has been provided, before they are enrolled in the study.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07855120
Effects of Hydrogen-rich Water Consumption on Transient Fatigue During an Official Football Match.
No phase
Palacky University
About 30 people
Starts Jan 20, 2027 (estimated)
In plain words A study of molecular Hydrogen in male participants 18 and older, run by Palacky University. It plans to enroll about 30 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists male participants 18 and older; healthy volunteers accepted. Conditions: Exercise-Induced Fatigue; Football Performance.
Male football players aged 18 years or older.
Currently competing in the second or third tier of the Czech national football league system.
At least 15 years of football experience.
Participation in at least four team training sessions per week in addition to regular competitive matches.
2 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Hydrogen-Rich Water (HRW); Placebo Water
Registered summary
The purpose of this study is to determine whether drinking hydrogen-rich water can reduce fatigue and help football players maintain high-intensity physical activity during an official football match. The study will include 30 male football players competing in the second and third tiers of the Czech national football league system. Participants will be randomly assigned to drink either hydrogen-rich water or placebo water. Neither the players nor the researchers conducting the assessments will know which type of water each participant receives until the study has been completed. The full summary is on the listing.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07098221
Hydrogen-Rich Water and Resting Metabolism in Young Adults
No phase
University of Novi Sad
About 24 people
Starts Sep 1, 2025 (estimated)
In plain words A study of molecular Hydrogen in people 18 and older, run by University of Novi Sad. It plans to enroll about 24 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older; healthy volunteers accepted. Conditions: Healthy Subjects or Volunteers.
Aged 18-35 years
BMI between 18.5 and 25.0 kg/m²
Apparently healthy, with no history of chronic disease
Non-smoker, not currently using nicotine-containing products
3 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Molecular Hydrogen; Placebo Comparator
Registered summary
The H2REST trial is a randomized, double-blind, placebo-controlled crossover study investigating the acute effects of a single dose of hydrogen-rich water (HRW) on resting metabolism in healthy young adults. Participants complete two testing sessions-receiving either HRW or placebo in a randomized order-followed by standardized metabolic testing. Primary outcomes include resting energy expenditure, respiratory exchange ratio, and substrate utilization measured via indirect calorimetry. The full summary is on the listing.
Where, as registered
No sites listed yet.
ClinicalTrials.gov lists 175 open registrations for this search, including ones where molecular Hydrogen is not a study arm or that are past the 9 we keep. Search them on ClinicalTrials.gov (opens in new tab).