Inulin (inulin-type fructans) trials recruiting now
34 registrations that name inulin as a study arm and are recruiting or about to, as ClinicalTrials.gov listed them on Oct 20, 2026. Read each listing for its full criteria and current status.
Kymata never assesses eligibility. Each listing names its own criteria; only its study team can say whether someone can join. Trial doses are given under the trial's monitoring and are not a schedule for anyone outside it.
Filter 34 registrations
Status
Phase
12US sites across 7 states
1
2 to 4
5 to 19
20 or more
All 34 registrations
RecruitingNCT06607523
The Gut-Brain Axis During Neurorehabilitation; Prebiotic Treatment to Alter the Gut Microbiome and Neurologic Symptoms
No phase
The University of Texas Medical Branch, Galveston
About 130 people
Started Mar 6, 2025
In plain words A study of inulin in people 18 and older, run by The University of Texas Medical Branch, Galveston. It plans to enroll about 130 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older; healthy volunteers accepted. Conditions: Brain Injuries.
Ages 18 and above
Admitted to Moody Neurorehabilitation Institute for care
Less than 6 months post-injury
English speaking
26 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Inulin
Registered summary
The aim of this study is to characterize the microbiome of patients undergoing post-acute residential neurorehabilitation compared to community controls and to determine if a dietary fiber, Inulin, can create a shift in the microbiome leading to changes in fatigue and cognition.
Where, as registered
1 US site in 1 state.
RecruitingNCT06372249
A Clinical Trial of Soluble Fiber for Asthma
Phase 2
Phoenix Children's Hospital
About 105 people
Started Nov 10, 2025
In plain words A Phase 2 study of inulin in people 6 to 17, run by Phoenix Children's Hospital. It plans to enroll about 105 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 6 to 17. Conditions: Asthma in Children.
Between ages 6-17
Asthma diagnosis within the last 2 years
Fractional excretion of exhaled nitric oxide (FeNO) > 50 ppb OR a clinical history of environmental allergies as defined by a positive skin prick or positive specific immunoglobulin E (IgE) tests to aeroallergens
No emergency department visits in the past 1 month
3 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Inulin
Registered summary
Randomized controlled trial of soluble fiber (Fruitafit Inulin). Participants will complete an ASA 24 dietary recall questionnaire to access their fiber intake. If eligible for the study, participants will be supplemented to their target fiber dosage with either soluble fiber (Fruitafit Inulin) or placebo. Collection of blood serum, fecal samples, and nasal wash will aid in analyzing the microbes present in one's gut and how fiber and diet may impact it. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT06668922
Irritable Bowel Syndrome and Control Volunteers: Diet Challenge
No phase
University of California, Los Angeles
About 72 people
Started Nov 28, 2024
In plain words A study of inulin in people 18 to 75, run by University of California, Los Angeles. It plans to enroll about 72 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 75; healthy volunteers accepted. Conditions: Irritable Bowel Syndrome (IBS).
Age 18-75
Individuals with irritable bowel syndrome (IBS)
Healthy volunteers (healthy controls) with no prior history of gastrointestinal (GI) disease or symptoms
No dietary restrictions other than vegetarian
The exclusion criteria are on the listing.
What it tests, as registered
Inulin
Registered summary
The study will investigate the relationship between fecal bile acids, short-chain fatty acids (SCFAs), and the gut microbiota in irritable bowel syndrome (IBS). The central hypothesis of this study is that specific shifts in the GI microbiome composition correlate with altered colonic SCFAs and BAs and contribute to IBS symptoms. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT07559227
Gut, Immune, and Vascular Health in Metabolically Healthy Obesity
No phase
Ball State University
About 70 people
Started Mar 1, 2026
In plain words A study of inulin in people 18 to 55, run by Ball State University. It plans to enroll about 70 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 55; healthy volunteers accepted. Conditions: Metabolically Healthy Obesity.
18-55 years old.
BMI is 18.5-24.9 kg/m2 or >30kg/m2 (part 1). BMI > 30 kg/m2 (part 2)
Not pregnant or expecting to become pregnant (females only).
Not postmenopausal (females only).
12 more inclusion criteria and the exclusion criteria are on the listing.
The investigators seek to better understand how a single high-fat meal impacts gut, immune, and vascular outcomes in individuals with "metabolically healthy obesity" (obesity and largely normal cardiometabolic profile) and "metabolically healthy normal-weight individuals." Second, the investigators seek to understand how a prebiotic fiber (inulin) impacts gut, immune, and vascular outcomes in individuals with "metabolically healthy obesity."
Where, as registered
1 US site in 1 state.
RecruitingNCT06866262
Inulin Gel in Combination With Ipilimumab and Nivolumab for the Treatment of Metastatic or Locally Advanced Kidney Cell Cancer, ICON Trial
Phase 1 and 2
University of Michigan Rogel Cancer Center
About 55 people
Started Aug 15, 2025
In plain words A Phase 1 and 2 study of inulin in people 18 and older, run by University of Michigan Rogel Cancer Center. It plans to enroll about 55 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Locally Advanced Clear Cell Renal Cell Carcinoma; Locally Advanced Sarcomatoid Renal Cell Carcinoma; Metastatic Clear Cell Renal Cell Carcinoma; Metastatic Sarcomatoid Renal Cell Carcinoma; Stage III Renal Cell Cancer AJCC v8; Stage IV Renal Cell Cancer AJCC v8.
Patient is ≥ 18 years of age on the day of signing informed consent.
Candidate for ipilimumab and nivolumab therapy for metastatic renal cancer per the treating physician investigator.
Patient has a performance status of ≤ 2 on the Zubrod performance scale.
Patient has a histological or cytological diagnosis of renal cancer with clear cell or sarcomatoid component.
16 more inclusion criteria and the exclusion criteria are on the listing.
This phase I/II trial tests the safety and effectiveness of inulin gel in combination with ipilimumab and nivolumab in treating patients with kidney cell cancer (renal cell carcinoma \[RCC\]) that has spread from where it first started (primary site) to other places in the body (metastatic) or has spread to nearby tissue or lymph nodes (locally advanced). Inulin is a common food additive fermentable prebiotic fiber beneficial for a healthy gut microbiome. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT06528041
Impact of Native Chicory Inulin on Change and Persistence of Gut Microbiota
No phase
Purdue University
About 52 people
Started Aug 1, 2024
In plain words A study of inulin in people 18 to 45, run by Purdue University. It plans to enroll about 52 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 45; healthy volunteers accepted. Conditions: Healthy.
adults aged 18-45
BMI >18.5 - < 30 kg/m2
Regular bowel movements (> 4 days per week)
The exclusion criteria are on the listing.
What it tests, as registered
Inulin; Maltodextrin
Registered summary
The main aim of this study is to investigate differences in rate, extent of change and persistence of the gut microbiota in healthy adult volunteers in response to native chicory inulin. Along with investigating the impact of native chicory on bowl habits, mood and appetite. The two main questions this study aims to answer: * To what extent do differences exist in rate of change over time between individuals in gut microbiota response (Bifidobacterium growth) to native chicory inulin supplementation. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT07724522
Prebiotic Inulin for Late-Reproductive Individuals
No phase
George Washington University
About 27 people
Started Aug 1, 2026
In plain words A study of inulin in female participants 40 to 55, run by George Washington University. It plans to enroll about 27 people at 1 US site.
Menstrual cycle irregularity (cycle length outside 21 - 35 days or variation > 7 days) or/and ≥ 2 skipped cycles and interval of ≥ 60 days of amenorrhea; with or without hot flashes or/and night sweats;
Weight stable within the last 3 months (body weight fluctuations within the 5% of their habitual body weight);
Spending ≥ 6 hours sitting;
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
Inulin; Maltodextrin (Placebo)
Registered summary
This study aims to evaluate the effects of 2 weeks of inulin supplementation in perimenopausal women with overweight or obesity. The primary questions this study seeks to answer are: 1. Does 2 weeks of inulin supplementation alter the gut and vaginal estrobolome compared with placebo? 2. Does 2 weeks of inulin supplementation affect cardiovascular health compared with placebo? 3. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT07095426
Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes
No phase
Ball State University
About 20 people
Started May 20, 2025
In plain words A study of inulin in people 18 to 55, run by Ball State University. It plans to enroll about 20 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 55; healthy volunteers accepted. Conditions: Metabolic Syndrome; Healthy Participants; Metabolically Healthy Obesity; Metabolically Abnormal Obesity.
Participants are 18-55 years old.
Participants BMI is ≥30 kg/m2 - this BMI requirement is due to our research aims.
Participants have either 0-1 or 2+ of the following risk factors outside of the normal reference ranges: blood pressure, blood sugar, triglycerides, and HDL-cholesterol.
Participants are not pregnant or expecting to become pregnant (females only). •Participants are not postmenopausal (females only).
9 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
inulin
Registered summary
Based on prior research, the investigators are interested in whether an intervention targeting gut health (supplemental fiber for 9 weeks total) will improve vascular health in individuals with obesity. Additionally, the investigators are interested in if this response differs based on whether individuals with obesity have very few heart disease risk factors or several heart disease risk factors.
Where, as registered
1 US site in 1 state.
RecruitingNCT06420401
Prebiotics and the Management of Hyperuricemia
No phase
Sun Yat-sen University
About 160 people
Started May 15, 2024
In plain words A study of inulin in people 18 to 80, run by Sun Yat-sen University. It plans to enroll about 160 people at 2 sites, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 80; healthy volunteers accepted. Conditions: Subjects With Hyperuricemia.
Local residents aged between 18-80 years old;
Stable weight (<5% weight change over the past 3 months);
Fsating uric acid > 420 umol/L for male and > 360 umol/L for female on two different days;
Not taking uric acid lowering drugs or have stopped taking uric acid lowering drugs for over 4 weeks at the time of recruitment;
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
araboxylan; inulin; inulin and araboxylan; placebo control
Registered summary
Hyperuricemia is a major risk factor for many chronic diesease. Recently, gut mcirobiota has been identified as a novel theraputic target for hyperuricemia. Both annimal studies and pilot human trials have demonstrated that administration of prebiotics help delay the progression of hyperuricemia throuh several mechanisms. This trial aims to examine its protective effects and potential mechanisms in clinical trials.
Where, as registered
No US site; China (2).
RecruitingNCT04578652
Fiber and Metformin Combination Therapy in Adolescents With Severe Obesity and Insulin Resistance
Phase 3
University of Alberta
About 90 people
Started Oct 22, 2021
In plain words A Phase 3 study of inulin in people 12 to 18, run by University of Alberta. It plans to enroll about 90 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 12 to 18. Conditions: Obesity, Childhood; Insulin Resistance.
Age 12-18 years
BMI percentile > 95% for age/sex;
Total weight fluctuation over past 6 months < 10%;
HOMA-IR > 3.16;
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
Metformin 850 mg oral tablet bid; Supplemental fiber mixture (35 g total) composed of 6g of Oligofructose + 12g of resistant maltodextrin + 12g of acacia gum + 5g of PGX.
Registered summary
This is a 12-month, single center, three-arm parallel design, double-blind, randomized clinical trial, to compare the effects of supplemental dietary fiber and metformin (MET) alone and in combination over 12 months on glucose metabolism (insulin resistance \[IR\]), inflammation and BMI in adolescents with obesity and IR, and to assess the relationship between therapeutic intervention(s) and changes in gut microbiome composition and function. The full summary is on the listing.
Where, as registered
No US site; Canada (1).
RecruitingNCT05353504
Impact of Microbiome-changing Interventions on Food Decision-making
No phase
Max Planck Institute for Human Cognitive and Brain Sciences
About 90 people
Started Mar 8, 2022
In plain words A study of inulin in people 18 to 60, run by Max Planck Institute for Human Cognitive and Brain Sciences. It plans to enroll about 90 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60; healthy volunteers accepted. Conditions: Overweight and Obesity.
BMI >= 25 kg/m2 or WHR >= 0.9/0.85 (m/d, f)
no MRI contra-indication
written informed consent
The exclusion criteria are on the listing.
What it tests, as registered
Inulin; Lifestyle intervention; Placebo
Registered summary
The investigators aim to test the hypothesis that a microbiome-changing dietary intervention improves food decision-making and to determine the underlying microbiotal and metabolic mechanisms. To this end, 90 overweight/obese adults will be enrolled in a randomized controlled trial to test the effects of a pre-biotic dietary intervention (supplementary intake of soluble fibre) or a behavioural lifestyle intervention (weekly educational program) vs. control condititon (supplementary intake of isocaloric starch) over a period of 26 weeks. The full summary is on the listing.
Where, as registered
No US site; Germany (1).
RecruitingNCT07592975
Effect of a Food Intervention With a Prebiotic Alone or Combined With B-vitamins on Gut Microbiota Diversity, Inflammation and Mental Health Outcomes in Older Adults (GutFood)
No phase
University of Ulster
About 84 people
Starts May 18, 2026 (estimated)
In plain words A study of inulin in people 50 and older, run by University of Ulster. It plans to enroll about 84 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 50 and older; healthy volunteers accepted. Conditions: Biomarkers of B-vitamin Status and Gut Microbiome Composition.
Community-dwelling
Non or low consumers (≤ 4 portions/week) of foods/beverages fortified with B-vitamins
Individuals with the capacity to provide informed consent
The exclusion criteria are on the listing.
What it tests, as registered
Inulin and B-vitamins; Inulin; Placebo
Registered summary
Ageing is associated with changes in gut microbiota composition, increased inflammation, and a greater risk of poor mental health outcomes. Nutritional inadequacies, including low dietary fibre intake and suboptimal B-vitamin status, are common in older adults and may contribute to these age-related health issues. Research suggests that increasing dietary fibre intake, particularly through prebiotics such as inulin, may help to improve gut health. In addition, B-vitamins have been linked to both gut and mental health, although their combined effects with prebiotics are not well understood. The full summary is on the listing.
Where, as registered
No US site; United Kingdom (1).
RecruitingNCT05946083
The Brain, the Bug, and the Binge: the Interplay Between Binge Drinking, Gut Microbiota, and Brain Functioning
Phase 2
University of Minho
About 82 people
Started Feb 24, 2023
In plain words A Phase 2 study of inulin in people 18 to 23, run by University of Minho. It plans to enroll about 82 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 23; healthy volunteers accepted. Conditions: Binge Drinking.
College students whose native language is Portuguese;
Age 18-23 years;
Binge Drinkers: report (i) drinking 4 (for women)/5 (for men) or more drinks on one occasion at least once a month, (ii) drinking at a speed of at least two drinks per hour during these episodes (which brings blood alcohol concentration to…
Non/Low-Drinkers: report (i) never drinking 4/5 or more drinks on one occasion and (ii) having an AUDIT score ≤ 4.
The exclusion criteria are on the listing.
What it tests, as registered
Inulin Intervention; Maltodextrin Intervention
Registered summary
Adolescence and youth are periods of significant maturational changes which seems to involve greater susceptibility to disruptive events in the brain such as binge drinking (BD). This prevalent pattern of consumption -characterized by repeated alcohol intoxications- is of special concern, as it has been associated with major neurocognitive impairments in the young brain. Recent studies indicate that alcohol may disrupt the gut microbiota (GM) and that these disruptions may lead to impairments in brain and behavior. The full summary is on the listing.
Where, as registered
No US site; Portugal (1).
RecruitingNCT07050888
Effect of Inulin Supplementation on Glycaemic Control and Immunological Parameters in Type 1 Diabetes (2024)
No phase
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
About 76 people
Started May 9, 2025
In plain words A study of inulin in people 18 to 70, run by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA). It plans to enroll about 76 people at 2 sites, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 70. Conditions: Type 1 Diabetes Mellitus.
A diagnosis of type 1 diabetes, as made by their primary clinician
A time in range of <80% in the last four weeks before screening
The exclusion criteria are on the listing.
What it tests, as registered
Inulin (prebiotic, fermentable fiber); Placebo
Registered summary
The goal is to establish the effect of oral inulin supplementation on continuous glucose monitoring (CGM) metrics and immunological parameters in adults with type 1 diabetes. The investigators will perform a double-blind, randomized, placebo-controlled trial in 2x38 participants to measure effects on CGM metrics, gut microbiome composition, residual beta cell and immunological parameters.
Where, as registered
No US site; Netherlands (2).
RecruitingNCT07665658
Effectiveness of Neuroplasticity-Targeted Supplements on Neuroinflammatory Markers, ADHD Symptom Severity, and Clinical Scores in Children
No phase
Khyber Medical University Peshawar
About 68 people
Started Mar 1, 2026
In plain words A study of inulin in people 6 to 12, run by Khyber Medical University Peshawar. It plans to enroll about 68 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 6 to 12. Conditions: Attention Deficit Hyperactivity Disorder.
DSM-5 confirmed ADHD diagnosis
Age 6-12 years
Medication-free or on stable stimulant medication (≥1 month)
This randomized controlled trial will evaluate the effectiveness of neuroplasticity-targeted supplements on neuroinflammatory markers and ADHD symptoms in children aged 6 to 12 years diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). Participants will be randomly assigned to one of four groups: gut-targeted supplements (prebiotics and probiotics), brain-targeted supplements (omega-3 fatty acids and vitamin B1), combined supplementation, or placebo. The intervention period will last 12 weeks. The full summary is on the listing.
Where, as registered
No US site; Pakistan (1).
RecruitingNCT05480696
Soluble Fibre Supplementation in NAFLD
Phase 2
McMaster University
About 60 people
Started Sep 9, 2022
In plain words A Phase 2 study of inulin in people 8 to 17, run by McMaster University. It plans to enroll about 60 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 8 to 17. Conditions: Non-Alcoholic Fatty Liver Disease; Non Alcoholic Steatohepatitis; Hepatic Steatosis.
Children ages 8-17 years
Diagnosed with obesity (BMI ≥2 standard deviations above WHO reference median)
Enrolled in GHWM Clinic
Clinical evidence of NAFLD (elevation of ALT, greater than 2x upper-limit-of-normal (ULN) \[ALT>80 IU/L for 8-17 years of age\], and hepatic steatosis measured as part of clinic enrolment).
The FIND study will look at the effect of a nutritional mixed fibre supplement, oligofructose and inulin (OF+INU), on children with non-alcoholic fatty liver disease. In this randomized, double- blind controlled trial, subjects will be given a supplement, in the form of oral pills, and will have bloodwork performed, their diets analyzed, and liver fat measured at several timepoints. Liver fat will be measured by using a specialized MRI device located at St. Joseph's Hospital. Subjects will be recruited from the Children's Exercise and Nutrition Clinic.
Where, as registered
No US site; Canada (1).
RecruitingNCT05791604
The Intervention of Obesity in Children With Prader-Willi Syndrome Using Prebiotics and Probiotics
No phase
Children's Hospital of Fudan University
About 60 people
Started Apr 1, 2023
In plain words A study of inulin in people 3 to 10, run by Children's Hospital of Fudan University. It plans to enroll about 60 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 3 to 10. Conditions: Prader-Willi Syndrome.
Pre-adolescent children with Prader Willi syndrome which were definitely diagnosed by gene testing.
Consistent with the diagnostic criteria for obesity.
Not participate in other research projects at present or three months before the research;
Agree to participate in the test and obtain the consent of their parents; voluntarily be the subjects and sign the informed consent form.
The exclusion criteria are on the listing.
What it tests, as registered
probiotics including B. lactis B420, B. lactis HN019, B. animalis Bb-12, L. rhamnosus GG; Prebiotics with galactomannan and oligofructose
Registered summary
Prader-Willi syndrome (PWS) is a rare genetic disease, with hyperappetite and severe obesity. At present, there is no effective drugs and interventions to help control the appetite of PWS patients. More and more evidence has shown that gut microbiota is closely related to obesity. Probiotics and prebiotics can improve the structure of gut microbiota, thus improve blood lipid levels and other biochemical indicators of obese people. Therefore, this study intends to explore the effectiveness and safety of probiotics and prebiotics in controlling appetite and weight gain of PWS children.
Where, as registered
No US site; China (1).
RecruitingNCT06541938
AIRE-2 Device for Study of Breath Analysis in IBD
No phase
McMaster University
About 60 people
Started Aug 28, 2024
In plain words A study of inulin in people 18 to 75, run by McMaster University. It plans to enroll about 60 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 75; healthy volunteers accepted. Conditions: Inflammatory Bowel Diseases.
Age 18-75 years old, confirmed diagnosis of IBD (UC or CD)
Under clinical remission for at least 3 months
Report having one or more IBS-like symptom (abdominal pain, altered bowel habit, flatulence, abdominal distension etc)
Own a smartphone with Bluetooth capability
3 more inclusion criteria and the exclusion criteria are on the listing.
The goal of this Prospective single-blinded intervention feasibility study is the utilization of the AIRE-2 device and FoodMarble app to elucidate the interplay among diet, symptoms, and microbial fermentable features in IBD patients with persistent intestinal symptoms and their household controls. AIRE-2 captures exhaled hydrogen and methane and FoodMarble app records breath levels, symptoms and dietary intake. The main questions it aims to answer are: 1. The full summary is on the listing.
Where, as registered
No US site; Canada (1).
RecruitingNCT07300553
Impact Of The Gut Microbiota On Host Cells Energy Metabolism in Health And In Inflammatory Bowel Disease
Phase 2
Assistance Publique - Hôpitaux de Paris
About 45 people
Started Jan 2, 2026
In plain words A Phase 2 study of inulin in people 18 to 50, run by Assistance Publique - Hôpitaux de Paris. It plans to enroll about 45 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 50; healthy volunteers accepted. Conditions: IBD; Crohn Disease; Ulcerative Colitis (UC).
Age ≥ 18 years and < 50 years
17 kg/m² < body mass index < 25 kg/m² (microbiota modified based on BMI, (Le Chatelier et al., 2013)
For women, female of child-bearing age with an active contraception (hormonal, intrauterine device, bilateral tubal occlusion, sexual abstinence*) and this during at least the period of treatment (up to v2) *Sexual abstinence is defined as…
A woman is considered of childbearing potential, i.e. fertile, following menarche and until becoming post-menopausal unless permanently sterile.
33 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Vancomycin /Amphotericin B (Fungizone®) /Gentamicine 80 mg; Inulin/Inulin C13
Registered summary
Inflammatory Bowel Disease (IBD) often leads to poor disease control and reduced quality of life. Changes in the gut microbiota may disrupt the energy metabolism of immune cells, contributing to IBD. This study will examine how gut microbiota affects immune cell metabolism in healthy adults and IBD patients. Healthy volunteers will be tested before and after a short antibiotic treatment, while IBD patients will be tested once. Energy metabolism will be measured using SCENITH, a method that analyzes metabolic activity in blood immune cells. The full summary is on the listing.
Where, as registered
No US site; France (1).
RecruitingNCT05071131
Effect of Inulin on Gut Microbiota and Gut Barrier in Chronic Kidney Disease
No phase
Charite University, Berlin, Germany
About 40 people
Started Feb 1, 2022
In plain words A study of inulin in people 18 to 75, run by Charite University, Berlin, Germany. It plans to enroll about 40 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 75. Conditions: Chronic Kidney Disease 5D.
Men and women in a ratio of 1:1
Age 18-75 years
Body mass index 25.0 - 39.9 kg/m\^2
End-stage kidney disease, which has been treated regularly with hemodialysis for at least 3 months
The exclusion criteria are on the listing.
What it tests, as registered
Inulin; Placebo
Registered summary
An adequate fiber intake is crucial for a well-balanced diet and reduces the risk of chronic diseases. However, nutritional recommendations for chronic kidney disease patients lead to an insufficient fiber intake with possible maladaptive effects on the gut microbiome. Therefore, we want to study the effects of a 35-day inulin supplementation on the gut microbiome, gut barrier function, bacterial metabolites and immune cell states in chronic kidney disease patients.
Where, as registered
No US site; Germany (1).
RecruitingNCT07810517
Lactobacillus Acidophilus and Inulin for Cognitive Impairment in Obesity
No phase
Anahuac University
About 40 people
Starts Nov 1, 2026 (estimated)
In plain words A study of inulin in people 30 to 40, run by Anahuac University. It plans to enroll about 40 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 30 to 40. Conditions: Obesity (Disorder).
Adults aged 30 to 40 years.
Diagnosis of obesity for more than 10 years.
Presence of mild cognitive impairment, evaluated using cognitive assessment scales.
BMI ≥30 kg/m².
2 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Synbiotic (Lactobacillus acidophilus LA-5 and Agave Inulin)
Registered summary
This randomized crossover clinical trial aims to evaluate the effect of a synbiotic containing Lactobacillus acidophilus and inulin on cognitive function in adults with obesity and mild cognitive impairment. Forty participants aged 30-40 years will be randomly assigned to two groups. Participants will receive either the synbiotic intervention or a control preparation, followed by crossover to the alternate intervention. Cognitive function will be evaluated using the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), and Memory Alteration Test (M@T). The full summary is on the listing.
Where, as registered
No US site; Mexico (1).
RecruitingNCT06551961
Effect of Chronic Feeding of Inulin And Methylcellulose on Colonic Fermentation
No phase
University of Nottingham
About 35 people
Started Sep 30, 2024
In plain words A study of inulin in people 18 to 65, run by University of Nottingham. It plans to enroll about 35 people at 2 sites, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 65; healthy volunteers accepted. Conditions: Irritable Bowel Syndrome.
• Aged between 18 and 65 years old.
Able to give informed consent.
Scoring ≤5 (i.e., mild, or less) for symptoms of flatulence, bloating, abdominal pain, loose stool, and hard stool in previous 2 weeks using a modified Gastrointestinal Symptom Rating Scale (5).
Agrees to consume the meals provided.
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
methylcellulose; inulin; maltodextrin
Registered summary
To determine the effect on tolerance and gas production from chronic feeding of fermentable fibre (inulin) incorporated into a gel forming fibre (methylcellulose) compared with placebo (maltodextrin)
Where, as registered
No US site; United Kingdom (2).
RecruitingNCT07487623
Evaluation of the Hepatoprotective Effects of a Nutritional Supplement in Patients With Liver Disease Secondary to Chronic Hepatitis C Virus Infection (RESQUETI Study).
No phase
University of Guadalajara
About 26 people
Started Oct 11, 2025
In plain words A study of inulin in people 18 to 69, run by University of Guadalajara. It plans to enroll about 26 people at 2 sites, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 69. Conditions: Liver Disease Chronic; HEPATITIS C VIRUS CHRONIC INFECTION.
What it tests, as registered
resveratrol, quercetin, taurine, whey protein, and inulin; whey protein
Registered summary
The purpose of this clinical trial is to evaluate whether a nutritional supplement containing resveratrol, quercetin, taurine, inulin, and whey protein improves biochemical and molecular markers, as well as clinical outcomes, in patients with liver disease related to chronic hepatitis C infection. The study will compare the investigational supplement with an active control (whey protein alone) to determine whether the combination formulation provides additional benefits on liver-related biomarkers and clinical assessment. The full summary is on the listing.
Where, as registered
No US site; Mexico (2).
RecruitingNCT07818369
Synbiotic LA-5 and Agave Inulin for Mild Cognitive Impairment
No phase
Anahuac University
About 20 people
Starts Dec 31, 2026 (estimated)
In plain words A study of inulin in people 60 to 75, run by Anahuac University. It plans to enroll about 20 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 60 to 75. Conditions: Cognitive Impairment.
Adults aged 60 to 75 years.
Presence of mild cognitive impairment (MCI) determined by neuropsychological testing, meeting at least two of the following three established cutoff criteria:
Montreal Cognitive Assessment (MoCA): 19-26 points.
Memory Alteration Test (M@T): 28-37 points.
2 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Synbiotic (Lactobacillus acidophilus LA-5 and Agave Inulin) Intervention Type:
Registered summary
This pilot randomized, double-blind, crossover clinical trial will evaluate the effect of a synbiotic containing Lactobacillus acidophilus LA-5 and agave inulin on mild cognitive impairment (MCI) in adults aged 60-75 years attending the Defense Medical Specialties Unit. Forty participants with MCI will be randomized into two groups of 20 participants. The intervention will consist of daily administration of L. acidophilus LA-5 (4 × 10⁹ CFU), 7 g of agave inulin, and almond powder for 12 weeks, while the control group will receive almond powder as the vehicle. The full summary is on the listing.
Where, as registered
No US site; Mexico (1).
Not yet recruitingNCT07525180
Comparing Prebiotic Fiber Supplements for Gut Health and Digestive Comfort
No phase
Ventoscity LLC
About 125 people
Starts Apr 15, 2026 (estimated)
In plain words A study of inulin in people 18 to 65, run by Ventoscity LLC. It plans to enroll about 125 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 65. Conditions: Healthy Participants.
Male or female adults aged 18 to 65 years
Body mass index 18.5 to 30 kg/m2
Habitual daily fiber intake of fewer than 10 grams per day, as self-reported at screening
No current use of fiber supplements, prebiotic supplements, or probiotic supplements
11 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
LOAM; Inulin; Cellulose Placebo
Registered summary
This study compares three dietary fiber supplements - LOAM prebiotic fiber, inulin, and a cellulose placebo - to evaluate their effects on intestinal gas production and gastrointestinal comfort in healthy adults who currently eat a low-fiber diet. Participants will be randomly assigned to one of the three supplements and asked to take one daily serving mixed with water for four weeks. Intestinal gas production will be measured using Ventos, a wearable device that continuously monitors intestinal gas when worn near the body. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
Not yet recruitingNCT07189585
Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis
Phase 2
Yale University
About 84 people
Starts Nov 1, 2026 (estimated)
In plain words A Phase 2 study of inulin in people 40 and older, run by Yale University. It plans to enroll about 84 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 40 and older. Conditions: Knee Osteoarthritis.
Provision of signed and dated informed consent form.
Stated willingness to comply with all study procedures and availability for the duration of the study (8 weeks).
Male or female, aged ≥ 40 years.
Established patient in the VA Connecticut Healthcare System
7 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
inulin; Maltodextrin (Placebo)
Registered summary
This study will test whether inulin, a type of dietary fiber, can reduce inflammation in older adults with knee osteoarthritis. Inflammation in the body may contribute to both joint pain and the progression of osteoarthritis. Inulin is a prebiotic fiber that may improve gut health and reduce lipopolysaccharide (LPS), a marker of bacterial products in the blood that is linked to inflammation. In this trial, participants with knee osteoarthritis will be randomly assigned to receive either inulin or a placebo (maltodextrin) for 8 weeks. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
Not yet recruitingNCT07856823
High-Resolution Measurements of Diet-Microbiome Interactions
No phase
Stanford University
About 40 people
Starts Oct 2026 (estimated)
In plain words A study of inulin in people 18 to 75, run by Stanford University. It plans to enroll about 40 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 75; healthy volunteers accepted. Conditions: IBS (Irritable Bowel Syndrome).
Age 18-75 years.
Able to provide written informed consent.
Able and willing to swallow capsules and complete all study procedures.
For the Healthy cohort: no history of a diagnosed chronic GI disorder and no ongoing GI symptoms warranting clinical evaluation.
2 more inclusion criteria and the exclusion criteria are on the listing.
The goal of this clinical trial is to characterize regional intestinal fermentation physiology and determine how the response to fermentable dietary fiber differs between healthy individuals and individuals with irritable bowel syndrome (IBS). The study will use ingestible capsule technologies to directly measure intestinal gases and regional microbiome composition following low-fiber and high-fiber meal challenges. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
Not yet recruitingNCT07840170
Whole Food Fibers for Support of Key Gut Bacteria for Human Health
No phase
Purdue University
About 24 people
Starts Nov 1, 2026 (estimated)
In plain words A study of inulin in people 18 to 65, run by Purdue University. It plans to enroll about 24 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 65. Conditions: Prediabetes or Overweight.
Overweight or obese, defined as a Body Mass Index (BMI) of 25 to 35 kg/m²
Prediabetic (HbA1c: 5.7 - 6.3), though otherwise healthy subjects
18-65 years age
The exclusion criteria are on the listing.
What it tests, as registered
Whole food fiber mixture; inulin
Registered summary
The purpose of this supplementation study is to understand how whole food fibers may affect gut microbiota composition and overall health. The investigators will enroll up to 24 people in this study. To be eligible, participants need to be between 18 and 65 years old, have a Body Mass Index of 25 to 35 kg/m², be prediabetic (HbA1c: 5.7 - 6.3), be free of any inflammatory bowel disease or any colon-related disease, be free of wheat allergens or intolerance, and not be pregnant or nursing. If participants have any questions about the criteria, they will ask the investigator consenting them. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
Not yet recruitingNCT07611552
Effects of Inulin on Cardiometabolic Risk Factors in Individuals Using Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA ) Medications for Weight Loss
No phase
Huazhong University of Science and Technology
About 600 people
Starts Jun 2026 (estimated)
In plain words A study of inulin in people 18 to 64, run by Huazhong University of Science and Technology. It plans to enroll about 600 people at 5 sites, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 64. Conditions: Obesity & Overweight.
Be overweight or obese (meeting any of the following criteria):
Obesity: BMI >=28 kg/m²;
Overweight (BMI >= 24 kg/m²) with at least one body weight-related comorbidity: obstructive sleep apnea syndrome, prediabetes, type 2 diabetes mellitus, hypertension, dyslipidemia, polycystic ovary syndrome, or non-alcoholic fatty liver…
Must have received GLP-1 RA drugs (Semaglutide, Liraglutide, Benaglutide, Tirzepatide, or Mazdutide) for weight-loss intervention for at least 3 months, and plan to continue using them for the next six months.
2 more inclusion criteria and the exclusion criteria are on the listing.
The goal of this double-blind randomized placebo-controlled supplement study is to investigate if the supplement of inulin (prebiotics, 10 grams per day) has beneficial effects on cardiometabolic risk factors in overweight or obese individuals receiving glucagon-like peptide-1 receptor agonists (GLP-1 RA) medications for weight loss.
Where, as registered
No US site; China (5).
Not yet recruitingNCT04698330
Effects Of Berberine Plus Inulin On Diabetes Care in Patients With LADA
Phase 4
Second Xiangya Hospital of Central South University
About 240 people
Starts May 2022 (estimated)
In plain words A Phase 4 study of inulin in people 18 to 70, run by Second Xiangya Hospital of Central South University. It plans to enroll about 240 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 70. Conditions: Type 1 Diabetes Mellitus; Autoimmune Diabetes.
Diabetes diagnosed according to the report of WHO in 1999；
Meet the Chinese Diabetes Society diagnostic criteria (2012) for LADA: (1)glutamic acid decarboxylase antibody (GADA) positive; (2) age at diagnosis ≧ 18 years old; (3) independent on insulin for more than 6 months after diagnosis;
Aged between 18 and 70 years old;
7.0%≤HbA1c ≤10.0%;
2 more inclusion criteria and the exclusion criteria are on the listing.
The primary purpose of this study is to evaluate the effects of oral berberine (BBR) and inulin combined with insulin therapy on diabetes care in patients with LADA.
Where, as registered
No US site; China (1).
Not yet recruitingNCT07537192
Inulin-Spirulina Co-intervention for Insomnia Disorder
No phase
First Affiliated Hospital of Zhejiang University
About 180 people
Starts May 1, 2026 (estimated)
In plain words A study of inulin in people 18 to 60, run by First Affiliated Hospital of Zhejiang University. It plans to enroll about 180 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 60. Conditions: Insomnia Disorder; Sleep Initiation and Maintenance Disorders.
Aged 18 to 60 years;
Meet the ICSD-3 diagnostic criteria for chronic insomnia disorder;
Pittsburgh Sleep Quality Index (PSQI) total score > 5;
Willing to participate and provide written informed consent.
The exclusion criteria are on the listing.
What it tests, as registered
Inulin; Spirulina; Maltodextrin
Registered summary
The goal of this clinical trial is to learn if inulin and spirulina, used alone or in combination, can improve insomnia disorder in adults aged 18 to 60 years with chronic insomnia disorder. It will also learn about the safety of these interventions. The full summary is on the listing.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07464691
Effect of Prebiotics in Saudi Adults With Type 2 Diabetes
No phase
Princess Nourah Bint Abdulrahman University
About 100 people
Starts Sep 13, 2026 (estimated)
In plain words A study of inulin in people 45 to 60, run by Princess Nourah Bint Abdulrahman University. It plans to enroll about 100 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 45 to 60; healthy volunteers accepted. Conditions: Type 2 Diabetes; Metabolic Health; Inflammation; Gut Microbiome; Obesity.
Saudi, both males and females.
Aged between 45-60 years old
BMI between 25 - 30 kg/m2
No antibiotic use for the last six months
6 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
oligofructose; Maltodextrin (Placebo)
Registered summary
This study will explore how a natural food ingredient called oligofructose affects blood glucose levels, lipid profiles, inflammation biomarkers, and gut bacteria in Saudi adults with type 2 diabetes. Oligofructose is a type of dietary fiber found in foods such as onions, garlic, and bananas. It is known to help the growth of "good" bacteria in the intestine, which may improve digestion and metabolism. A total of 100 adults (50 with type 2 diabetes and 50 without diabetes) will take part in this research. The full summary is on the listing.
Where, as registered
No US site; Saudi Arabia (1).
Not yet recruitingNCT05860322
The Effect of Inulin Supplementation on Colorectal Surgery Outcomes
No phase
Centre hospitalier de l'Université de Montréal (CHUM)
About 40 people
Starts Aug 1, 2023 (estimated)
In plain words A study of inulin in people 18 and older, run by Centre hospitalier de l'Université de Montréal (CHUM). It plans to enroll about 40 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Anastomotic Complication.
Patients with a colorectal cancer and who present for elective colorectal surgery
The exclusion criteria are on the listing.
What it tests, as registered
Inulin; Placebo
Registered summary
Colorectal cancer (CRC) is the third most diagnosed cancer in Canada. The most common surgical procedure in patients with CRC is an intestinal resection followed by a reconnection to rejoin the ends of the remaining bowel. Among the postoperative complications, leaking of this intestinal connection is notably feared, affecting up to 20% of patients. These leaks are characterized by impaired intestinal healing and are associated with severe infections and even death. The full summary is on the listing.
Where, as registered
No US site; Canada (1).
Not yet recruitingNCT07565675
The BALANCE Study - Improving Glucose Control Through Prebiotic Gut Health Drink in Postmenopausal Women
No phase
University of Roehampton
About 30 people
Starts Jun 10, 2026 (estimated)
In plain words A study of inulin in female participants 45 to 60, run by University of Roehampton. It plans to enroll about 30 people at 1 site, none in the US.
Post-menopausal (no menstrual period for ≥12 months)
No serious long-term medical conditions
Living in the UK
10 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
ió everyday (a prebiotic- enriched gut health drink containing inulin); Placebo Comparator
Registered summary
The menopausal transition is associated with a decline in oestrogen levels, contributing to adverse metabolic changes including increased central adiposity, systemic inflammation, and insulin resistance. These changes are linked to a higher risk of developing type 2 diabetes in postmenopausal women. Recent evidence suggests that the gut microbiota plays an important role in metabolic regulation and glucose homeostasis. Menopause-related hormonal changes may alter the composition and function of the gut microbiome, with downstream effects on insulin sensitivity. The full summary is on the listing.