30 registrations that name hyaluronic Acid as a study arm and are recruiting or about to, as ClinicalTrials.gov listed them on Oct 20, 2026. Read each listing for its full criteria and current status.
Kymata never assesses eligibility. Each listing names its own criteria; only its study team can say whether someone can join. Trial doses are given under the trial's monitoring and are not a schedule for anyone outside it.
Filter 30 registrations
Status
Phase
2US sites across 1 state
1
2 to 4
5 to 19
20 or more
All 30 registrations
RecruitingNCT05018481
HA35 Moderate Alcoholic Hepatitis (AH) Study
Early phase 1
The Cleveland Clinic
About 54 people
Started Sep 1, 2022
In plain words An early phase 1 study of hyaluronic Acid in people 21 to 65, run by The Cleveland Clinic. It plans to enroll about 54 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 21 to 65. Conditions: Alcoholic Hepatitis.
Clinical diagnosis of alcoholic hepatitis defined as:
Regular consumption of alcohol with an intake of >60 g daily or >420 g weekly on average for men and >40 g daily or >280 g weekly on average for women for 6 months or more
MELD <21
Serum total bilirubin >3 mg/dL
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
Sodium Hyaluronate; Placebo
Registered summary
Eligible participants will be asked to take a placebo/treatment capsule for 90 days and participate in two in-person study visits, one at the start of the 90 days and the second at the completion of study supplement administration. Both visits will include a physical exam, clinical labs, body composition measurements, muscle strength tests, questionnaires, and urine and stool collections. Additionally, a sugar cocktail will be consumed to measure gut permeability and a muscle biopsy will be collected. The day after the visits, you will need to return to drop off the 24-hour urine collection. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT05025865
HA35 Acute Alcohol Study
Early phase 1
The Cleveland Clinic
About 24 people
Started Feb 1, 2022
In plain words An early phase 1 study of hyaluronic Acid in people 21 to 65, run by The Cleveland Clinic. It plans to enroll about 24 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 21 to 65; healthy volunteers accepted. Conditions: Healthy Controls.
Alcohol consumption of less than 7 drinks per week for women and less than 14 drinks per week for men
Ability to understand and willingness to provide written consent
The exclusion criteria are on the listing.
What it tests, as registered
Sodium Hyaluronate; Placebo
Registered summary
Eligible subjects will be asked to take a placebo/treatment capsule for a total of 3 days and then participate in a study visit on the fourth day. This study visit will include a medical exam, clinical labs, questionnaires, body composition measurements, and urine and stool collections. Additionally, participants will consume a sugar cocktail to measure their gut permeability, participate in an acute ethanol challenge, and undergo two muscle biopsies. The study will take approximately 3-4 hours and a designated driver will need to drive the participant home. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT07308015
Clinical Study on the Treatment of Rhinitis Sicca With Sodium Hyaluronate Adjustable Nasal Irrigator
Phase 4
China-Japan Union Hospital
About 200 people
Started Jun 16, 2025
In plain words A Phase 4 study of hyaluronic Acid in people 18 to 75, run by China-Japan Union Hospital. It plans to enroll about 200 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 75. Conditions: Rhinitis Sicca.
Symptoms: Dry nose sensation, little and thick nasal discharge, nosebleeds, itchy nasal cavity, and dryness in the nasopharynx.
To observe the therapeutic effect of sodium hyaluronate adjustable nasal irrigator on various types of rhinitis sicca and compare it with the therapeutic effect of the commonly used physiological seawater nasal spray in clinical practice.
Where, as registered
No US site; China (1).
RecruitingNCT07542808
An Open-Label, Double-Treatment Group Study to Evaluate the Efficacy and Safety of Human Allogeneic Bone-Marrow- Derived Mesenchymal Stromal Cell Product StromaForte Compared With Hyaluronic Acid for the Treatment of Knee Osteoarthritis
Phase 2 and 3
Cellcolabs Clinical SPV Limited
About 140 people
Starts Apr 27, 2026 (estimated)
In plain words A Phase 2 and 3 study of hyaluronic Acid in people 18 and older, run by Cellcolabs Clinical SPV Limited. It plans to enroll about 140 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Knee Arthritis Osteoarthritis.
Willing and able to provide written informed consent and comply with all procedures required by the protocol.
Aged ≥ 18 years at the time of signing the informed consent form.
Diagnosed with knee osteoarthritis (OA) based on the criteria established by the American College of Rheumatology, confirmed through radiological images no older than three months.
Grade I to IV osteoarthritis on the Kellgren-Lawrence radiological classification scale.
2 more inclusion criteria and the exclusion criteria are on the listing.
the Effect of Hyaluronic Acid Intrauterine Wash on Endometrial Receptivity and Pregnancy Outcome
Phase 2
Al-Nahrain University
About 120 people
Started Sep 1, 2023
In plain words A Phase 2 study of hyaluronic Acid in female participants 18 to 40, run by Al-Nahrain University. It plans to enroll about 120 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists female participants 18 to 40. Conditions: Infertile Patients.
Infertile females aged 18-40 years.
Infertile females scheduled for GnRH antagonist protocol of fresh ICSI cycle.
Females use dual stimulation (GnRH agonist plus Ovetrelle) for ovulation triggering.
The exclusion criteria are on the listing.
What it tests, as registered
Hyaluronic Acid (HA); platlet rich plasma (PRP)
Registered summary
Hyaluronic acid intrauterine wash is done for infertile females undergoing intracytoplasmic sperm injection on the day of oocyte retrieval. endometrial receptivity parameters, including the subendometrial vasculature indices were measured before and after the intervention for purpose of studying the effect of hyaluronic acid on improvement of the endometrial receptivity and subsequently the pregnancy outcome
Where, as registered
No US site; Iraq (1).
RecruitingNCT06237647
Comparison of Steroid, PRP,and PRP Plus Hyaluronic Acid Injection for Rotator Cuff Lesions.
No phase
Tien-Ching Lee
About 80 people
Started Feb 17, 2023
In plain words A study of hyaluronic Acid in people 20 to 85, run by Tien-Ching Lee. It plans to enroll about 80 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 20 to 85. Conditions: Rotator Cuff Lesions.
A. Shoulder pain for at least 1 months
B.partial-thickness tear diagnosed by MRI or Echo
C.age between 20 and 85 years old
The exclusion criteria are on the listing.
What it tests, as registered
Hyaluronic acid, HA
Registered summary
Rotator cuff tear is a common cause of shoulder pain. Steroids, hyaluronic acid (HA), and platelet-rich plasma (PRP) injections are becoming popular for the treatment of chronic rotator cuff partial tear. The investigators plan to evaluate the effect of the new product of PRP combined with HA on the rotator cuff and prove its benefit of pain control and function recovery.
Where, as registered
No US site; Taiwan (1).
RecruitingNCT07458334
Skincare Benefits of Kaempferol-Containing Masks
No phase
Kaohsiung Medical University Chung-Ho Memorial Hospital
About 60 people
Started Feb 9, 2026
In plain words A study of hyaluronic Acid in female participants 25 to 60, run by Kaohsiung Medical University Chung-Ho Memorial Hospital. It plans to enroll about 60 people at 1 site, none in the US.
This is an open-label, two-arm study, which will evaluate the effects of Kaempferol-containing masks on skin biophysical properties
Where, as registered
No US site; Taiwan (1).
RecruitingNCT07825155
Ultrasound-Guided Injection of Carpal Tunnel Syndrome Using Hyaluronic Acid vs Corticosteroid vs Glucose 5%
Early phase 1
Tanta University
About 60 people
Started Mar 15, 2026
In plain words An early phase 1 study of hyaluronic Acid in people 18 to 70, run by Tanta University. It plans to enroll about 60 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 70. Conditions: Carpal Tunnel Syndrome (CTS).
What it tests, as registered
Hyaluronic Acid- corticosteroid- 5% glucose
Registered summary
Carpal tunnel syndrome (CTS) is a common peripheral nerve entrapment disorder caused by compression of the median nerve at the wrist. This study is a comparative study designed to evaluate the efficacy of three ultrasound-guided injection treatments for patients with mild to moderate CTS: hyaluronic acid (HA), corticosteroid, and 5% glucose (D5W). A total of 60 adult patients with clinically and electrophysiologically confirmed mild to moderate CTS will be enrolled and divided into three groups of 20 patients each. The full summary is on the listing.
Where, as registered
No US site; Egypt (1).
RecruitingNCT07666347
Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis
No phase
Tanta University
About 50 people
Started Jun 24, 2026
In plain words A study of hyaluronic Acid in people 50 and older, run by Tanta University. It plans to enroll about 50 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 50 and older. Conditions: Intraarticular Injection; Botox; Hyaluronic Acid; Knee Osteoarthritis.
Age ≥ 50 years.
Both genders.
Chronic knee osteoarthritis (KOA) according to American College of Rheumatology criteria for the diagnosis of knee osteoarthritis.
Third or fourth grade Kellgren and Lawrence system for classification of osteoarthritis based on radiological data, it is a common method of classifying the severity of osteoarthritis (OA) using five grades according to the following sites…
The exclusion criteria are on the listing.
What it tests, as registered
Hyaluronic acid; Botulinum toxin type A
Registered summary
This study aims to compare the efficacy of intra-articular injection of Botulinum toxin and hyaluronic acid on pain in knee osteoarthritis.
Where, as registered
No US site; Egypt (1).
RecruitingNCT06694532
EffIcacy Between Arthrocentesis With High Versus Low Molecular Weight Hyaluronic Acid in Treatment of TMJ Disorders
Phase 1 and 2
Basel khaled mohamed
About 30 people
Started Oct 31, 2023
In plain words A Phase 1 and 2 study of hyaluronic Acid in people 18 to 100, run by Basel khaled mohamed. It plans to enroll about 30 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 100. Conditions: Temporomandibular Joint Disorders; Arthrocentesis.
Pain or tenderness of the jaw
Pain in one or both of the temporomandibular joints
Aching pain in and around your ear
Difficulty chewing or pain while chewing
2 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Hyaluronic acid; Syringes
Registered summary
The study will be carried out in Patients in two Groups aged between 17 to 70 years , of both sexes, who had painful symptoms, with or without presence of joint noise, and had unilateral or bilateral internal derangement of the TMJ proven by clinical examination, with no improvement after conservative treatment.
Where, as registered
No US site; Egypt (1).
RecruitingNCT07548203
Clinical Evaluation of Different Treatments for Interdental Black Triangles
No phase
Ain Shams University
About 30 people
Starts Apr 22, 2026 (estimated)
In plain words A study of hyaluronic Acid in people 18 to 50, run by Ain Shams University. It plans to enroll about 30 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 50. Conditions: Black Triangles Syndrome (BTS); Papilla Reconstruction.
This randomized clinical trial aims to evaluate and compare the effectiveness of surgical and nonsurgical treatment approaches for the management of interdental black triangles. Black triangles are open gingival embrasures caused by the loss or deficiency of the interdental papilla between adjacent teeth. These spaces are a common esthetic concern and may also contribute to food impaction and periodontal problems. The full summary is on the listing.
Where, as registered
No US site; Egypt (1).
Not yet recruitingNCT07819461
A Study to Evaluate Efficacy and Safety of a Single Intra-Articular Injection of HL-01 in the Treatment of Pain in Symptomatic Knee Osteoarthritis
Phase 3
IBSA Institut Biochimique SA
About 704 people
Starts Sep 30, 2026 (estimated)
In plain words A Phase 3 study of hyaluronic Acid in people 40 to 80, run by IBSA Institut Biochimique SA. It plans to enroll about 704 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 40 to 80. Conditions: Osteo Arthritis of the Knee.
Age is between 40 and 80 years of age
Have symptoms of knee osteoarthritis (OA) for at least 6 months
Meet American College of Rheumatology criteria (clinical and radiological) for knee OA
Body mass index (BMI) is less than or equal to 40 kg/m2
6 more inclusion criteria and the exclusion criteria are on the listing.
The goal of this clinical trial is to test HL-01 in patients with knee osteoarthritis pain. The main question\[s\] it aims to answer are: * Measure the change in average daily knee pain intensity scores from baseline to the end of the study using a pain scale that measures pain on a scale of 0 to 10 * Measure the change in WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) scales measuring knee pain, stiffness, and function from baseline to the end of the study * Measure the change in EuroQol EQ-5D-5L quality of life assessments from baseline to end of the study * Measure… The full summary is on the listing.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07869576
Cryopreserved Pre-embryo Transfer in a Cytokine-rich Medium Versus Hyaluronic Acid
No phase
Vida Recoletas Sevilla
About 610 people
Starts Oct 2026 (estimated)
In plain words A study of hyaluronic Acid in female participants 18 to 50, run by Vida Recoletas Sevilla. It plans to enroll about 610 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists female participants 18 to 50. Conditions: Frozen Embryo Transfer (FET).
Women aged 18 to 50 years.
Undergoing transfer of a single cryopreserved embryo (SET) from own and/or donor gametes.
The exclusion criteria are on the listing.
What it tests, as registered
Cytokine-rich embryo transfer medium; Hyaluronic acid-enriched embryo transfer medium
Registered summary
This multicenter, randomized, double-blind study compares a GM-CSF-enriched embryo transfer medium with a hyaluronic acid-enriched medium in women undergoing single frozen embryo transfer. It will assess whether the GM-CSF medium is non-inferior for clinical pregnancy rates. Participants will be randomly assigned to one of the two groups.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07581548
Evaluation of the Effectiveness of Three Tear Substitute Formulations in Postoperative Discomfort After Cataract Surgery
Observational
Democritus University of Thrace
About 300 people
Starts May 1, 2026 (estimated)
In plain words An observational study of hyaluronic Acid in people 45 to 85, run by Democritus University of Thrace. It plans to enroll about 300 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 45 to 85. Conditions: Cataract; Dry Eye.
What it tests, as registered
Sodium Hyaluronate 0.15% and Dexpanthenol 2% drops (Hylopan max); Sodium Hyaluronate 0.15% and Trehalose 3% drops (Thealoz duo); Sodium Hyaluronate 0.2% and Amino acids drops (Helenvision ultra)
Registered summary
The primary objective of this study is the assessment of three tear substitute formulations in terms of postoperative discomfort following cataract extraction surgery by means of phacoemulsification and intraocular lens implantation.
Where, as registered
No US site; Greece (1).
Not yet recruitingNCT06818487
Ganyan-1 in Dry Eye
No phase
Beijing Tongren Hospital
About 219 people
Starts Jul 1, 2025 (estimated)
In plain words A study of hyaluronic Acid in people 18 to 70, run by Beijing Tongren Hospital. It plans to enroll about 219 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 70. Conditions: Dry Eye; TCM.
What it tests, as registered
Ganyan1; Sodium Hyaluronate; 1/2Ganyan1; Placebo
Registered summary
Ganyan -1 for the patients with dry eye
Where, as registered
No sites listed yet.
Not yet recruitingNCT07536971
Clinical Study of i-PRF Intrauterine Perfusion for Endometrial Regeneration and Repair in Moderate to Severe Intrauterine Adhesions
No phase
Beijing Obstetrics and Gynecology Hospital
About 200 people
Starts May 1, 2026 (estimated)
In plain words A study of hyaluronic Acid in female participants 18 to 40, run by Beijing Obstetrics and Gynecology Hospital. It plans to enroll about 200 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists female participants 18 to 40. Conditions: Intrauterine Adhesions.
Female participants aged 20 to 40 years
Moderate to severe intrauterine adhesions caused by endometrial injury, defined according to the Chinese diagnostic and grading standard (CSGE score >=9)
Strong desire for fertility
Normal ovarian function
3 more inclusion criteria and the exclusion criteria are on the listing.
Intrauterine adhesions (IUA) caused by endometrial basal layer injury can lead to reduced menstrual flow, infertility, recurrent pregnancy loss, and poor reproductive outcomes. Hysteroscopic adhesiolysis with uterine cavity reconstruction is the standard treatment, but women with moderate to severe IUA still have high rates of re-adhesion and unsatisfactory endometrial repair after surgery. Injectable platelet-rich fibrin (i-PRF) is an autologous blood-derived biologic material that can be prepared at the bedside. The full summary is on the listing.
Where, as registered
No US site; China (1).
Not yet recruitingNCT07236632
Hyaluronic Acid vs Botulinum Toxin Injection in Treatment of Lifelong Drug-Resistant Premature Ejaculation: Randomized Study
No phase
Benha University
About 80 people
Starts Dec 15, 2025 (estimated)
In plain words A study of hyaluronic Acid in male participants 22 to 45, run by Benha University. It plans to enroll about 80 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists male participants 22 to 45. Conditions: Premature Ejaculation.
Adult male patients aged 22 to 45 years.
Sexually active and in a stable heterosexual relationship.
Circumcised.
Able to understand and comply with study procedures and follow-up visits.
3 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Botulinum toxin type A; Hyaluronic acid
Registered summary
Premature ejaculation (PE) is one of the most common male sexual dysfunctions, often resistant to conventional pharmacological and behavioral treatments. This randomized clinical trial aims to compare the safety and efficacy of two minimally invasive treatment options - hyaluronic acid (HA) injection into the glans penis versus botulinum toxin type A injection into the bulbospongiosus muscle - in men with lifelong drug-resistant premature ejaculation. Eighty participants will be randomly assigned in a 1:1 ratio to receive either HA or botulinum toxin injection. The full summary is on the listing.
Where, as registered
No sites listed yet.
Not yet recruitingNCT06878599
Intratympanic Injection of Dexamethasone With Hyaluronic Acid in Treatment of Sudden Sensorineural Hearing Loss
Phase 4
Assiut University
About 70 people
Starts May 1, 2025 (estimated)
In plain words A Phase 4 study of hyaluronic Acid in people 18 and older, run by Assiut University. It plans to enroll about 70 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Sudden Sensorineural Hearing Loss (SSNHL).
Adult patients (aged 18 and over)
Patients with sudden sensory neural hearing loss (SSNHL)
The exclusion criteria are on the listing.
What it tests, as registered
Hyaluronic Acid (HA); Dexamethasone
Registered summary
* To evaluate efficacy of intratympanic injection of dexamethasone and hyaluronic acid mixture as a treatment modality in cases of sudden sensorineural hearing loss (SSNHL). * To compare outcomes of intratympanic injection of dexamethasone and hyaluronic acid mixture to dexamethasone alone in treatment of SSNHL.
Where, as registered
No US site; Egypt (1).
Not yet recruitingNCT07736781
Research Title: Long Term Functional Outcome of a Single Hyaluronic Acid Injection in Improving Symptoms and Function in Patients With Knee Osteoarthritis - A Single-Arm Open-Label Study (DIART ONE).
Phase 3
Universiti Sains Malaysia
About 62 people
Starts Aug 30, 2026 (estimated)
In plain words A Phase 3 study of hyaluronic Acid in people 40 to 70, run by Universiti Sains Malaysia. It plans to enroll about 62 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 40 to 70. Conditions: Osteo Arthritis of the Knee.
What it tests, as registered
Hyaluronic Acid (HA)
Registered summary
This study aims to evaluate the effectiveness of a single HA injection in improving pain, function, and quality of life in patients with knee OA over a 12-month period. By focusing on a single-arm open-label design, this study will provide practical insights into the real-world application of this treatment approach.
In plain words A study of hyaluronic Acid in people 45 to 80, run by Taipei Medical University. It plans to enroll about 60 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 45 to 80. Conditions: Knee Pain Chronic.
Aged 45 to 80 years.
Knee osteoarthritis classified as Ahlbäck stage I or II, or Kellgren-Lawrence grade <3.
A Visual Analogue Scale (VAS) pain score ≤3.
A Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score >2 or a total WOMAC score >12.
The exclusion criteria are on the listing.
What it tests, as registered
Placebo; A+HA premium oral hyaluronic acid drink
Registered summary
Evaluate the effect of A+HA premium oral hyaluronic acid drink on relieving knee pain.
Where, as registered
No US site; Taiwan (1).
Not yet recruitingNCT07337863
Phase II/III Randomized Trial of UC-MSC Secretome vs Sodium Hyaluronate in Knee Osteoarthritis
Phase 2 and 3
Universitas Sriwijaya
About 50 people
Starts Aug 30, 2026 (estimated)
In plain words A Phase 2 and 3 study of hyaluronic Acid in people 40 to 70, run by Universitas Sriwijaya. It plans to enroll about 50 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 40 to 70. Conditions: Knee Osteoarthritis (Knee OA).
Diagnosed with primary OA in one or both knees based on American College of Rheumatology (Clinical and Rheumatology criteria).
Males or females in the age range 40-70 years
Symptomatic knee OA (defined by pain at the affected joint for at least 3 months before inclusion and visual analog scale 40 - 70 mm on a 100 mm Visual Analog Scale (VAS).
Radiographic evidence of grade 2 to 3 osteoarthritis (OA) based on Kellgren and Lawrence radiographic criteria.
3 more inclusion criteria and the exclusion criteria are on the listing.
This study is a randomized, double-blind, multicenter Phase II/III clinical trial designed to evaluate the effectiveness and safety of umbilical cord-derived mesenchymal stem cell (UC-MSC) secretome compared with sodium hyaluronate in patients with knee osteoarthritis. Knee osteoarthritis is a common degenerative joint disease that causes chronic pain and functional limitation. Participants will be randomly assigned to receive intra-articular injections of either UC-MSC-derived secretome or sodium hyaluronate. The full summary is on the listing.
Where, as registered
No US site; Indonesia (1).
Not yet recruitingNCT07665619
Clinical Efficacy of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Combined With Sodium Hyaluronate Intravesical Instillation in the Treatment of Radiation Cystitis
Early phase 1
Fujian Medical University Union Hospital
About 48 people
Starts Jul 20, 2026 (estimated)
In plain words An early phase 1 study of hyaluronic Acid in female participants 18 to 80, run by Fujian Medical University Union Hospital. It plans to enroll about 48 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists female participants 18 to 80. Conditions: Radiation Cystitis.
Female participants aged 18-80 years.
History of pelvic radiotherapy, with completion of radiotherapy at least 6 months prior to enrollment.
Clinically diagnosed with radiation cystitis accompanied by persistent lower urinary tract symptoms, such as urinary frequency, urgency, hematuria, or related symptoms.
Able and willing to provide written informed consent.
The exclusion criteria are on the listing.
What it tests, as registered
Exosomes (hUC-MSC-Exo); Sodium Hyaluronate (Hyalein); Normal Saline (0.9% NaCl)
Registered summary
The goal of this clinical trial is to learn whether intravesical instillation of human umbilical cord mesenchymal stem cell-derived exosomes combined with sodium hyaluronate is safe and effective for treating radiation cystitis. Radiation cystitis is a complication that may occur after pelvic radiotherapy. Common symptoms include blood in the urine, frequent urination, urgent urination, and painful urination. The full summary is on the listing.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07697196
Effect of EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid on HPV DNA Integration
No phase
IRCCS San Raffaele
About 42 people
Starts Jul 2026 (estimated)
In plain words A study of hyaluronic Acid in female participants 25 and older, run by IRCCS San Raffaele. It plans to enroll about 42 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists female participants 25 and older. Conditions: HPV Infection; HPV Integration; HPV Disease; HPV Genital Infection; HPV Persistence; Low Grade Squamous Intraepithelial Lesions of the Cervix.
Age ≥ 25 years old
Positive HPV DNA test with genotyping 9-24 months prior to Day 0
Positive HPV DNA test with genotyping at Day 0
Presence of an HPV-related cervical lesion within 5-24 months prior to Day 0. This lesion will be defined alternatively as:
6 more inclusion criteria and the exclusion criteria are on the listing.
This interventional, single-center, open-label randomized clinical study evaluates the efficacy of an oral dietary supplement (Pervistop®) in women with persistent Human Papillomavirus (HPV) infection. The supplement is a combination of four natural molecules: Epigallocatechin gallate (EGCG), folic acid (FA), vitamin B12 (B12), and hyaluronic acid (HA).The primary objective is to describe the effect of this association on HPV DNA integration into the host genome by measuring the clearance rate of viral oncoproteins E6 and E7. The full summary is on the listing.
Where, as registered
No US site; Italy (1).
Not yet recruitingNCT07750756
Hyaluronic Acid vs I-PRF With Microneedling in Enhancing Peri-implant Soft Tissue
Phase 2 and 3
Ain Shams University
About 42 people
Starts Oct 30, 2026 (estimated)
In plain words A Phase 2 and 3 study of hyaluronic Acid in people 21 to 50, run by Ain Shams University. It plans to enroll about 42 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 21 to 50. Conditions: Peri-implant Mucosa Thickness.
Patients with delayed implants placed in the maxillary esthetic region in correct positioning and angulation
Patients with peri-implant gingival thickness ≤ 1 mm
Patients with healthy gingiva and who can maintain good oral hygiene around implants
The exclusion criteria are on the listing.
What it tests, as registered
Hyaluronic Acid (HA); Platelet rich fibrin
Registered summary
This study aims to compare the use of microneedling alone versus with hyaluronic acid or i-PRF in conjunction with microneedling in peri-implant mucosa in the esthetic zone to test the superior increase in gingival thickness.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07205640
Improving Healing in Children After Tooth Extraction Using Laser Therapy or Hyaluronic Acid
No phase
Cairo University
About 36 people
Starts Dec 1, 2025 (estimated)
In plain words A study of hyaluronic Acid in people 6 to 10, run by Cairo University. It plans to enroll about 36 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 6 to 10; healthy volunteers accepted. Conditions: Mesh; Healthy Volunteer; Low Level Laser Therapy; Hyaluronic Acid Gel for Preservation the Extraction Socket; Extraction Socket Healing; Badly Decayed Molars; Tooth Extraction Site Healing.
Children aged from six to ten years.
Children of both genders.
Children with badly decayed first permanent molar beyond repair and indicated for extraction.
Parents acceptance to participate in the study.
The exclusion criteria are on the listing.
What it tests, as registered
Low-Level Laser Therapy; Hyaluronic Acid (HA)
Registered summary
Tooth extraction may be an unpleasant and painful experience for children, Post-extraction wound healing. Low-level laser therapy (LLLT) is a widely used adjuvant treatment for wound healing, resulting in both an increase in cell number and an increase in cell metabolism. HA it is an important component of the extracellular matrix and a constituent of the neural, connective, and epithelial tissues.
Where, as registered
No US site; Egypt (1).
Not yet recruitingNCT07504250
Hyaluronic Acid vs Mitomycin-C in External Dacryocystorhinostomy
Phase 4
All India Institute of Medical Sciences, Bhubaneswar
About 36 people
Starts Apr 1, 2026 (estimated)
In plain words A Phase 4 study of hyaluronic Acid in people 18 to 65, run by All India Institute of Medical Sciences, Bhubaneswar. It plans to enroll about 36 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 65. Conditions: Dacryocystitis.
All patients within age group 18-65 years diagnosed with chronic dacryocystitis due to Primary Acquired Nasolacrimal Duct Obstruction (PANDO) qualifying for external dacryocystorhinostomy
Patients with resolved acute dacryocystitis
The exclusion criteria are on the listing.
What it tests, as registered
Hyaluronic Acid (HA); Mitomycin -C
Registered summary
RCT to compare the surgical success in patients undergoing external dacryocystorhinostomy with intraoperative Mitomycin-C (0.4 mg/ml) Vs Hyaluronic acid 1% (1ml) as adjuvant, To compare the complication rates and wound healing patterns in each group, To Compare change in tear MMP-9 levels from preoperative (within 1 week before surgery) to postoperative (6 weeks after surgery) , To compare the comfort levels of patients in each group.
Where, as registered
No sites listed yet.
Not yet recruitingNCT06324474
Clinical and Immunological Evaluation of HA in Treatment of Periodontitis
No phase
Sana'a University
About 24 people
Starts Apr 2025 (estimated)
In plain words A study of hyaluronic Acid in people 20 to 60, run by Sana'a University. It plans to enroll about 24 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 20 to 60; healthy volunteers accepted. Conditions: Periodontitis.
systemically healthy.
at least 20 teeth and suffers from moderate <7mm to severe. >8mm.periodontitis with probing depth >5m and in the contralateral side.
ability to attend to the clinic in a regular manner.
The exclusion criteria are on the listing.
What it tests, as registered
Hyaluronic acid; scaling and root planning
Registered summary
To evaluate the immunological effectiveness of Hyaluronic acid as adjunction treatment to scaling and root planning and scaling and root planning alone. Comparison between clinical measurement before and after treatment. Evaluate the level of IGF-1 in treated site as immunological marker if periodontal regeneration.
Where, as registered
No US site; Yemen (1).
Not yet recruitingNCT07844928
Blue®M Gel Versus Hyaluronic Acid for Stability of Immediately Loaded Dental Implants
No phase
Mansoura University
About 24 people
Starts Sep 12, 2026 (estimated)
In plain words A study of hyaluronic Acid in people 18 to 45, run by Mansoura University. It plans to enroll about 24 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 45. Conditions: Dental Implants; Immediate Dental Implant Loading; Implant Stability.
Patients aged 18-45 years.
Patients with one or more missing teeth in the posterior maxilla.
Adequate bone volume (width ≥ 6 mm and height ≥ 12 mm from maxillary sinus floor).
Good oral hygiene and motivation for oral rehabilitation.
The exclusion criteria are on the listing.
What it tests, as registered
Blue®M Gel; Hyaluronic Acid
Registered summary
This randomized controlled clinical trial aims to compare the effect of topical oxygen therapy (Blue®M Gel) and hyaluronic acid on the stability of immediately loaded dental implants placed in the posterior maxilla. Twenty-four dental implants will be placed in eligible patients and randomly assigned to one of three groups: control implants without surface treatment, implants immersed in Blue®M Gel before placement, and implants immersed in hyaluronic acid gel before placement. The full summary is on the listing.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07658118
Safety and Preliminary Efficacy of Endoscopic Submucosal Injection of Hyaluronic Acid Into the Bladder Wall in Patients With Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
Phase 1
Sverdlovsk Regional Clinical Hospital No.1
About 15 people
Starts Jul 2026 (estimated)
In plain words A Phase 1 study of hyaluronic Acid in people 18 and older, run by Sverdlovsk Regional Clinical Hospital No.1. It plans to enroll about 15 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Cystitis, Interstitial; Chronic Pain.
Men and women aged ≥ 18 years.
Confirmed diagnosis of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) based on cystoscopic findings (glomerulations after hydrodistension or Hunner's lesions).
Refractory to at least 2 lines of standard therapy (e.g., dietary modifications, oral medications, intravesical hyaluronic acid instillations, hydrodistension) for ≥ 6 months.
Pain score ≥ 4 on a 0-10 Visual Analog Scale (VAS) at screening.
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
Hyaluronic Acid (HA)
Registered summary
The goal of this pilot clinical trial is to learn if injecting hyaluronic acid into the bladder wall is safe and if it works to reduce pain and urinary frequency in people with interstitial cystitis (IC), also called bladder pain syndrome (BPS). Who can take part? Adults aged 18 and older who have IC/BPS that did not get better after at least two standard treatments (such as diet changes, oral drugs, or bladder instillations) for 6 months or more. The full summary is on the listing.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07862686
Hyaluronic Acid Combined With Xenograft Versus Xenograft Alone in Immediate Implant Placement
No phase
Cairo University
About 12 people
Starts Sep 2026 (estimated)
In plain words A study of hyaluronic Acid in people 18 and older, run by Cairo University. It plans to enroll about 12 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Immediate Implant Placement in the Esthetic Zone; NON-RESTORABLE TOOTH IN ESTHETIC ZONE.
Non-restorable tooth in the esthetic zone.
Thin labial plate of bone (≤1 mm) maintained after tooth extraction.
Teeth with no acute inflammation.
Thick soft tissue biotype.
5 more inclusion criteria and the exclusion criteria are on the listing.
This randomized controlled clinical trial aims to compare the clinical and radiographic outcomes of immediate implant placement using xenograft combined with hyaluronic acid versus xenograft alone in the esthetic zone. Patients requiring extraction of a non-restorable tooth followed by immediate implant placement will be randomly allocated to two groups. In the intervention group, the jumping gap between the implant and facial bone wall will be grafted with xenograft combined with hyaluronic acid, while in the control group, xenograft alone will be used. The full summary is on the listing.