32 registrations that name creatine monohydrate as a study arm and are recruiting or about to, as ClinicalTrials.gov listed them on Oct 20, 2026. Read each listing for its full criteria and current status.
Kymata never assesses eligibility. Each listing names its own criteria; only its study team can say whether someone can join. Trial doses are given under the trial's monitoring and are not a schedule for anyone outside it.
Filter 32 registrations
Status
Phase
12US sites across 10 states
1
2 to 4
5 to 19
20 or more
All 32 registrations
RecruitingNCT06112990
Creatine Supplementation and Resistance Training to Preserve Muscle Mass and Attenuate Cancer Progression
Phase 3
University of Utah
About 200 people
Started Nov 9, 2023
In plain words A Phase 3 study of creatine monohydrate in male participants 18 and older, run by University of Utah. It plans to enroll about 200 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists male participants 18 and older. Conditions: Metastatic Prostate Cancer.
Subject age ≥ 18 years old.
Metastatic castration-sensitive prostate cancer patients who have not met criteria for disease progression (per Prostate Cancer Working Group guidelines) on current systemic therapy
Currently treated with surgical castration or medical castration with Gonadotropin-releasing hormone (GnRH) agonists/antagonists, and/or an androgen receptor pathway inhibitor (ARPI)) aka novel hormone therapy (e.g., abiraterone,…
Eastern Cooperative Oncology Group (ECOG) Performance Status ≤ 2
8 more inclusion criteria and the exclusion criteria are on the listing.
The goal of this clinical trial is to test the use of creatine monohydrate supplementation with resistance training to preserve muscle mass and help lessen prostate cancer progression. The main question it aims to answer is if this treatment will help maintain muscle mass to help in reducing fatigue and improving physical function, independence, and quality of life. Participants will be asked to participate in a 52-week exercise intervention consisting of a twice weekly telehealth resistance training program.
Where, as registered
1 US site in 1 state.
RecruitingNCT07029243
Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis
No phase
University of California, San Francisco
About 100 people
Started Apr 15, 2026
In plain words A study of creatine monohydrate in people 18 and older, run by University of California, San Francisco. It plans to enroll about 100 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Cirrhosis; Frailty; Sarcopenia.
Confirmed diagnosis of cirrhosis by ICD-10 code, liver biopsy, abdominal imaging, or transient elastography
Access to digital device and internet at home
Ability to provide written informed consent before any study-related activities
Ability to remain in study for at least 3 months
The exclusion criteria are on the listing.
What it tests, as registered
HEAL-ME digital app; Creatine supplementation; Whey protein supplementation; Placebo
Registered summary
Frailty and muscle health are important for patients with chronic liver disease. This study looks at the use of a digital prehabilitation app (HEAL-ME) plus creatine and whey protein combination supplementation on maintaining muscle health in patients with liver disease. The investigators anticipate that this combination of supplementation and nutrition/exercise prehabilitation app will maintain muscle health in patients with liver disease.
Where, as registered
1 US site in 1 state.
RecruitingNCT06395506
THRIVE Well Cancer FDTN/Exercise_Creatine Supplementation
No phase
The University of Texas Medical Branch, Galveston
About 60 people
Started Oct 29, 2024
In plain words A study of creatine monohydrate in female participants 18 to 75, run by The University of Texas Medical Branch, Galveston. It plans to enroll about 60 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists female participants 18 to 75; healthy volunteers accepted. Conditions: Breast Cancer; Breast Cancer Female; Muscle Weakness.
Age 18-75 years of age
Diagnosis of breast cancer requiring chemotherapy
Recent (within 6 months) completion of chemotherapy
Willing to attend 3 virtual-based exercise sessions per week
3 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Creatine
Registered summary
The study's purpose is to evaluate whether creatine supplementation can help breast cancer survivors respond quicker to exercise by improving strength, endurance, and body composition. We are seeking to compare information collected from healthy woman of the same age who have never had breast cancer to those participants who have had breast cancer and undergone chemotherapy treatment.
Where, as registered
1 US site in 1 state.
RecruitingNCT07756658
The Effects of Tyrosol and Creatine on Exercise Performance and Cognition in Healthy Adults
No phase
Applied Science & Performance Institute
About 60 people
Started Sep 4, 2026
In plain words A study of creatine monohydrate in male participants 20 to 55, run by Applied Science & Performance Institute. It plans to enroll about 60 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists male participants 20 to 55; healthy volunteers accepted. Conditions: Tyrosol; Creatine; Endurance Performance; Cognition; Mood.
Healthy males aged 20-55
Currently active (engaged in moderate to vigorous activity at least 2-days per week as defined by the American College of Sports Medicine Guidelines)
Estimated VO2 max greater than the 40th percentile of the population norm for age (assessed via ACSM guidelines, 2014).
Able to read and write in English
2 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Tyrosol; Creatine Monohydrate; Resistant Dextrin
Registered summary
This study will be a randomized, double-blind, placebo-controlled trial. It will be conducted over a 8-week intervention investigating the effects of creatine (5g Creatine monohydrate); placebo control (5g resistant dextrin), and a combination group containing both creatine and tyrosol (5g creatine monohydrate + 150mg tyrosol/day). Endurance, strength, cognition, and fatigue resistance will be examined through repeated strength and endurance testing (described below). The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT07766395
A Clinical Trial to Evaluate the Effects of a Powder Supplement in Supporting Lean Muscle Development, Hormone-Related Wellness, Digestive Comfort, Dermatologic Health, and Overall Wellness
No phase
Clean Nutraceuticals
About 35 people
Starts Sep 2026 (estimated)
In plain words A study of creatine monohydrate in people 21 to 45, run by Clean Nutraceuticals. It plans to enroll about 35 people at 1 US site.
Engages in structured physical activity ≥3 times per week, with each session lasting at least 30 minutes, (e.g., running, gym/strength training, cycling, team sports, fitness classes).
Anyone with a menstrual cycle between 24-38 days.
8 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Shelf Builder Women's Creatine Powder
Registered summary
This study will evaluate the effects of Clean Nutra's Shelf Builder Women's Creatine Powder on lean muscle development, hormone-related wellness, digestive comfort, dermatological health, and overall wellness. The study is a single-arm, open-label, virtual trial in which all 35 enrolled participants will use the test product once daily for eight weeks. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT02568878
Creatine for Depressed Male and Female Methamphetamine Users
Phase 3
Montana State University
About 29 people
Started Nov 2015
In plain words A Phase 3 study of creatine monohydrate in people 18 to 59, run by Montana State University. It plans to enroll about 29 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 59. Conditions: Depression; Anxiety; Methamphetamine Dependence.
Current primary diagnosis of methamphetamine dependence or abuse, with methamphetamine preferred drug of abuse
Current diagnosis of major depressive disorder (primary or substance-induced)
Current diagnosis of an anxiety disorder (primary or substance-induced)
Current Hamilton Depression Rating scale score > or = to 16
2 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Creatine monohydrate
Registered summary
* Assess the antidepressant/anxiolytic effect of creatine in male and female methamphetamine users * Assess creatine's effect on methamphetamine use * Assess the safety of creatine in male methamphetamine users with depression
Where, as registered
1 US site in 1 state.
RecruitingNCT06208813
Creatine Supplementation in Concussion Recovery
No phase
San Diego State University
About 20 people
Started Feb 1, 2024
In plain words A study of creatine monohydrate in people 18 to 35, run by San Diego State University. It plans to enroll about 20 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 35. Conditions: Concussion, Brain.
18-35 years old with a diagnosed concussion within 72 hours post-injury
The exclusion criteria are on the listing.
What it tests, as registered
Creatine
Registered summary
The proposed study aims to compare concussion recovery in those supplementing creatine and those not supplementing creatine. Specific aim 1: To compare number of days until asymptomatic between those taking creatine vs. those not taking creatine following a concussion. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT07472426
Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat
No phase
University of Northern Iowa
About 20 people
Starts Mar 12, 2026 (estimated)
In plain words A study of creatine monohydrate in people 18 to 45, run by University of Northern Iowa. It plans to enroll about 20 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 45; healthy volunteers accepted. Conditions: Acute Kidney Injury; Exertional Heat Illness.
Age range: 18-45 years old
Physical Activity Level: Classified as 'active' using the criteria of engaging in planned exercise at least 3x/week, for a minimum of 30 minutes per session, over the past 3 months
Aerobic Fitness Level: Subjects must have an aerobic fitness classification of at least 'good' per American College of Sports Medicine (ACSM) criteria and assessed via maximal oxygen uptake test
Health Status: Free of any known cardiovascular, metabolic, renal, or neurologic conditions.
3 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Creatine Monohydrate; Maltodextrin (Placebo)
Registered summary
The goal of this clinical trial is to learn if one week of creatine monohydrate supplementation alters inflammation, markers of acute kidney injury (AKI) risk, and cognitive performance in active, young, healthy volunteers. The main questions it aims to answer are: 1. Does one-week of creatine supplementation alter urinary markers of inflammation (cytokines) during exercise in the heat when compared to placebo? 2. Does one-week of creatine supplementation alter markers of AKI during exercise in the heat when compared to placebo? 3. The full summary is on the listing.
Where, as registered
1 US site in 1 state.
RecruitingNCT07579455
Acute Pharmacokinetics of Create Wellness Gummies in Healthy Adults
No phase
University of Oklahoma
About 16 people
Starts Jun 2026 (estimated)
In plain words A study of creatine monohydrate in people 18 to 45, run by University of Oklahoma. It plans to enroll about 16 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 45; healthy volunteers accepted. Conditions: Creatine Absorption in Healthy Adults.
Adults between the ages of 18-45 yrs
Body mass index of <35 kg/m2
Recreationally active \[(≥30 minutes of moderate-intensity physical activity per week as defined by the International Physical Activity Questionnaire (IPAQ)\]
Healthy and free from major diseases as determined from screening call and health history questionnaire.
1 more inclusion criterion and the exclusion criteria are on the listing.
The purpose of this study is to compare blood creatine levels following acute oral supplementation of Create Wellness creatine gummies to creatine monohydrate powder.
Where, as registered
1 US site in 1 state.
RecruitingNCT07177183
Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure
No phase
University Hospital Ostrava
About 492 people
Starts Feb 2, 2026 (estimated)
In plain words A study of creatine monohydrate in people 18 and older, run by University Hospital Ostrava. It plans to enroll about 492 people at 2 sites, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Prolonged Mechanical Ventilation; Critical Illness.
Patients <18 years of age
Patients admitted to post-ICU care units at Chronicare Group a.s. in the Czech Republic within 12 months
The exclusion criteria are on the listing.
What it tests, as registered
Dietary supplement creatine; Dietary supplement - placebo; No intervention
Registered summary
The main objective of the study is to determine whether a subnormal serum creatinine value upon admission to the Post-ICU Care Unit predicts the need for prolonged ventilatory support. A parallel objective of the study is to determine whether exogenous in-take of the dietary supplement creatine in patients with subnormal serum creatinine value is associated with a shortened duration of ventilatory support and improved patients outcome.
Where, as registered
No US site; Czechia (2).
RecruitingNCT06925880
Effect of Micronized Creatine Monohydrate on Muscle Mass, Strength and Performance in Older Adults Submitted to Total Knee Arthroplasty
No phase
Consorci Sanitari del Maresme
About 262 people
Started Jun 10, 2025
In plain words A study of creatine monohydrate in people 65 and older, run by Consorci Sanitari del Maresme. It plans to enroll about 262 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 65 and older. Conditions: Sarcopenia in Elderly; Frailty at Older Adults; Functional Capacity; Creatine Supplementation; Arthroplasties, Knee Replacement; Physical Performance.
Persons 65 years of age or older who have been operated on for the first time for total knee arthroplasty,
who are undergoing an outpatient rehabilitation program according to standard clinical practice,
who sign the informed consent form.
The exclusion criteria are on the listing.
What it tests, as registered
Creatine Monohydrate; Placebo
Registered summary
Double-blind randomized placebo-controlled clinical trial with two parallel arms. The main objective is to evaluate the efficacy and safety of creatine supplementation in older adults who have been operated on for total knee arthroplasty and undergoing a usual rehabilitation program. The intervention will consist of daily creatine monohydrate supplementation for 12 weeks. The intervention will start after surgery with a loading dose of 20g/day for 1 week and then continue with a maintenance dose of 5g/day for 11 weeks. The full summary is on the listing.
Where, as registered
No US site; Spain (1).
RecruitingNCT06948149
Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment
No phase
Western University, Canada
About 140 people
Started Jan 1, 2026
In plain words A study of creatine monohydrate in people 60 and older, run by Western University, Canada. It plans to enroll about 140 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 60 and older. Conditions: Creatine; Exercise; Mild Cognitive Impairment (MCI).
What it tests, as registered
Creatine monohydrate; Resistance training
Registered summary
The goal of this 26-week trial is to learn if creatine supplementation and resistance training (i.e., weightlifting; exercise that increases muscle mass), alone and together, impact cognition, brain health, and physical function in older adults with mild cognitive impairment. Previous studies have shown that resistance training improves cognition and brain health in older adults. Creatine is naturally occurring in the human body and is known to decline with age. Studies have shown that creatine increases muscle mass and bone density in older adults when supplemented. The full summary is on the listing.
Where, as registered
No US site; Canada (1).
RecruitingNCT05589064
Evaluation of the Impact of a Dietary and Nutritional Intervention on Persistent Post-concussive Symptoms
No phase
Universite de Moncton
About 120 people
Started Oct 1, 2022
In plain words A study of creatine monohydrate in people 16 and older, run by Universite de Moncton. It plans to enroll about 120 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 16 and older. Conditions: Brain Injury Traumatic Mild.
16 years or older
Must be able to understand English or French
Have persistent post-concussive symptoms lasting at least 2 weeks but no longer than 6 months
The exclusion criteria are on the listing.
What it tests, as registered
Experimental: Dietetic counseling; Active Comparator: Omega-3, vitamin D3 and creatine monohydrate; Other : Physiotherapy treatment
Registered summary
Concussions affect thousands of Canadians every year. Although the effects are usually temporary, 10-15% of adults experience persistent symptoms likely to last several weeks or even months. It is suggested that nutritional interventions should be considered in concussion management because nutrition can act on several mechanisms of brain injury. However, to date, no study has assessed the impact of dietary interventions on the recovery of people with persistent post-concussive symptoms. The full summary is on the listing.
Where, as registered
No US site; Canada (1).
RecruitingNCT06677359
Impact of Creatine Monohydrate Micronized Supplementation With or Without Multicomponent Training in Older Adults.
No phase
Fundacion Miguel Servet
About 120 people
Started Nov 30, 2024
In plain words A study of creatine monohydrate in people 75 and older, run by Fundacion Miguel Servet. It plans to enroll about 120 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 75 and older; healthy volunteers accepted. Conditions: Functionality; Cognition; Strength Training Effects.
Age: 75 years or older.
Able to ambulate with or without personal/technical assistance.
Life expectancy ≥ 6 months.
Barthel Index \> 60.
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
Creatine Group; Placebo Group; Multicomponent Training
Registered summary
The goal of this clinical trial is to study and evaluate whether a protocol of creatine supplementation, with or without multicomponent training, improves functional and cognitive capacity in individuals over 75 years old. The results of this study will further our understanding of creatine supplementation effects in the context of older patients and in combination with multicomponent training, thereby enhancing patient care strategies. Additionally, the goal is to improve the quality of life for the elderly and the efficiency of the healthcare system. The full summary is on the listing.
Where, as registered
No US site; Spain (1).
RecruitingNCT06576466
Effect of Supplementation With Creatine on the Recovery of Ischemic Stroke
No phase
Fundació d'investigació Sanitària de les Illes Balears
About 92 people
Started Sep 27, 2024
In plain words A study of creatine monohydrate in people 18 to 80, run by Fundació d'investigació Sanitària de les Illes Balears. It plans to enroll about 92 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 80. Conditions: Stroke, Ischemic.
Age between 18 and 80 years
Recent diagnosis of ischemic stroke (from 24 hours to 5 days) .
Neurological deficit due to the stroke that affects mobility (paresis and/or ataxia) and requires motor rehabilitation.
Ability to understand and sign the informed consent form, or failing that, have sufficient support to carry out the correct follow-up of the study.
The exclusion criteria are on the listing.
What it tests, as registered
Creatine monohydrate; Placebo
Registered summary
Stroke is a leading cause of disability and the second leading cause of death worldwide. Most strokes are ischemic, caused by acute arterial occlusion. Post-stroke treatment focuses on secondary prevention and rehabilitation, but few treatments address functional recovery. Creatine, a supplement known for improving physical performance, may aid in the recovery of stroke patients, reducing sarcopenia and improving strength among other effects. The full summary is on the listing.
Where, as registered
No US site; Spain (1).
RecruitingNCT07625202
Creatine Supplementation During GLP-1a Therapy
No phase
University of Saskatchewan
About 40 people
Started May 25, 2026
In plain words A study of creatine monohydrate in people 18 and older, run by University of Saskatchewan. It plans to enroll about 40 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older; healthy volunteers accepted. Conditions: Sarcopenia.
Starting GLP-1 agonist therapy
18 years of age or older
The exclusion criteria are on the listing.
What it tests, as registered
Dietary supplementation during a 12 week resistance-training program (creatine); Dietary supplementation during a 12 week resistance-training program (placebo)
Registered summary
GLP-1 receptor agonists are effective for weight loss, but significant muscle mass is lost as a proportion of this weight loss. This study combines resistance-training and creatine supplementation to try to prevent this loss of muscle mass.
Where, as registered
No US site; Canada (1).
RecruitingNCT07729930
Dietary Supplements and Middle Aged Women (Creatine)
No phase
Loughborough University
About 38 people
Started May 1, 2026
In plain words A study of creatine monohydrate in female participants 35 to 65, run by Loughborough University. It plans to enroll about 38 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists female participants 35 to 65; healthy volunteers accepted. Conditions: Cognition; Muscle Strength; Fatigue Symptom; Blood Pressure and Augmentation Index; Body Composition Changes; Sleep; Gastrointestinal Comfort; Quality of Life; Joint Pain; Inflammation Biomarkers; Bone Metabolism Biomarkers; Menopause Symptoms.
Female
Aged 35-65 years old
Healthy, free from known disease
Non-smoker
2 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Creatine Monohydrate; Placebo control
Registered summary
This study will examine the effects of combining different types of dietary supplements on various aspects of health and wellbeing in middle aged women. The main outcomes of the trial will be aspects of health and wellbeing that middle aged women report as increasingly problematic, such as joint pain, fatigue, sleep, and changes in body composition, strength, and inflammation. Participants will consume the supplement(s) or placebo for 8 weeks, and outcome measures will be assessed before and after supplementation.
Where, as registered
No US site; United Kingdom (1).
RecruitingNCT07463092
Creatine Supplementation and Resistance Training to Improve Sarcopenia Parameters in Patients With Prostate Cancer After Androgen Deprivation Therapy
No phase
University of Sao Paulo
About 34 people
Started May 1, 2026
In plain words A study of creatine monohydrate in male participants 40 and older, run by University of Sao Paulo. It plans to enroll about 34 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists male participants 40 and older. Conditions: Prostate Cancer; Sarcopenia.
Men aged ≥ 40 years;
Patients with histologically or cytologically confirmed localized prostate cancer;
Patients who have undergone surgical castration or pharmacological castration with gonadotropin-releasing hormone (GnRH/LHRH) agonists or antagonists for at least six months prior to the start of the intervention;
Patients receiving continuous or intermittent androgen deprivation therapy;
4 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Creatine Monohydrate; Maltodextrin; Resistance training
Registered summary
This randomized, double-blind, placebo-controlled clinical trial will investigate the effects of creatine supplementation combined with a 12-week supervised resistance training program on muscle mass, muscle strength, physical performance (e.g., parameters of sarcopenia), and muscle density in men with prostate cancer undergoing androgen deprivation therapy (ADT). ADT often causes loss of lean mass, reduced muscle strength, functional impairment, and increased fat mass. The full summary is on the listing.
Where, as registered
No US site; Brazil (1).
RecruitingNCT06937190
Pre-Sleep Creatine Enhances Anaerobic Power in Recreationally Active Females
No phase
Ankara Yildirim Beyazıt University
About 24 people
Started Apr 1, 2025
In plain words A study of creatine monohydrate in female participants 18 to 25, run by Ankara Yildirim Beyazıt University. It plans to enroll about 24 people at 1 site, none in the US.
This study is a randomized, double-blind, placebo-controlled trial designed to examine the effects of pre-sleep creatine monohydrate supplementation on anaerobic performance and muscle damage markers in recreationally active females. Participants will be randomly assigned to receive either 5 grams of creatine monohydrate or a placebo 30 minutes before sleep for seven consecutive days. Anaerobic performance will be assessed using the Wingate Anaerobic Test, evaluating peak and average power output and fatigue index. The full summary is on the listing.
Where, as registered
No US site; Iran (1).
RecruitingNCT07451496
PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)
No phase
National University of Singapore
About 20 people
Started Sep 29, 2025
In plain words A study of creatine monohydrate in people 50 to 80, run by National University of Singapore. It plans to enroll about 20 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 50 to 80; healthy volunteers accepted. Conditions: Ageing.
Age 50-80 years (both male and female)
Relatively healthy and in stable health condition
Not engaged in regular resistance or aerobic training in the past 12 months (i.e., untrained)
VO₂peak below the 75th percentile for age- and sex-specific norms
6 more inclusion criteria and the exclusion criteria are on the listing.
As the population ages, the growing prevalence of age-related diseases is creating substantial challenges for healthcare systems worldwide. Current therapeutic strategies often target individual diseases and decrease mortality without improving healthspan. The geroscience hypothesis suggests that targeting the ageing process itself could prevent, delay, or manage the severity of multiple age-related diseases concurrently, thereby improving overall healthspan and reducing healthcare burdens. The full summary is on the listing.
Where, as registered
No US site; Singapore (1).
Not yet recruitingNCT07795853
Creatine for Recovery and Thinking in Mothers
No phase
University of North Carolina, Chapel Hill
About 40 people
Starts Sep 8, 2026 (estimated)
In plain words A study of creatine monohydrate in female participants 18 to 45, run by University of North Carolina, Chapel Hill. It plans to enroll about 40 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists female participants 18 to 45. Conditions: Post-partum; Women.
6 weeks -12 months postpartum
Body mass index of 18.5-34.9 kg/m2
Cleared to resume physical activity
The exclusion criteria are on the listing.
What it tests, as registered
Creatine Monohdyrate
Registered summary
The purpose of this randomized, double-blind, parallel-group trial is to compare the effects of two doses of creatine monohydrate (5 g/day versus 10 g/day) administered for four weeks in postpartum women. The study will evaluate exercise performance, post-exercise recovery, cognitive function, and brain creatine concentrations in a sub-sample.
Where, as registered
1 US site in 1 state.
Not yet recruitingNCT07838090
Resistance Training and Creatine Supplementation for Head and Neck Cancer
No phase
Medical University of South Carolina
About 30 people
Starts Nov 15, 2026 (estimated)
In plain words A study of creatine monohydrate in people 18 and older, run by Medical University of South Carolina. It plans to enroll about 30 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Head and Neck Cancer; Cancer Survivorship; Treatment-related Muscle Loss; Physical Function.
Age 18 years or older.
Diagnosis of head and neck cancer (AJCC stages I-IV).
Completed curative-intent primary treatment, including surgery, radiation, chemotherapy, or combination treatment, within the past 1 to 3 months.
Clearance to engage in moderate-intensity exercise based on the American College of Sports Medicine (ACSM) Preparticipation Screening Guidelines.
5 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Creatine Supplementation; Resistance Training
Registered summary
The study will examine a 10-week resistance training program, with or without creatine monohydrate supplementation, in adult survivors of head and neck cancer. Participants will undergo screening and complete study assessments before and after the training period and at a follow-up evaluation. The study will evaluate feasibility, safety, body composition, physical function, cancer-related fatigue, quality of life, and symptom burden in this population.
Where, as registered
1 US site in 1 state.
Not yet recruitingNCT07712653
Effects of Creatine and Carbohydrate Supplementation on Endurance Performance
No phase
California Polytechnic State University-San Luis Obispo
About 12 people
Starts Jul 15, 2026 (estimated)
In plain words A study of creatine monohydrate in people 18 to 40, run by California Polytechnic State University-San Luis Obispo. It plans to enroll about 12 people at 1 US site.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 40; healthy volunteers accepted. Conditions: Exercise Performance Recovery.
healthy (i.e. no known cardiovascular disease)
nonsmoking
active (regular physical activity ≥150 minutes per week of aerobic exercise and have a VO2 peak ≥35 ml/kg-min)
a normal BMI (18.5 - 35 kg/m\^2)
1 more inclusion criterion and the exclusion criteria are on the listing.
What it tests, as registered
Creatine Monohydrate; Carbohydrate; Creatine Monohydrate and Carbohydrate; placebo solution
Registered summary
This study will examine the independent and combined effects of creatine and carbohydrate supplementation on exercise performance, compared to placebo.
Where, as registered
1 US site in 1 state.
Not yet recruitingNCT07372144
Creatine and Cognitive Health in Patients With Early-stage Breast Cancer During and After Chemotherapy Treatment
Phase 3
D'Or Institute for Research and Education
About 227 people
Starts Aug 1, 2026 (estimated)
In plain words A Phase 3 study of creatine monohydrate in people 18 and older, run by D'Or Institute for Research and Education. It plans to enroll about 227 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 and older. Conditions: Breast Cancer.
Age ≥18 years.
Histologically confirmed invasive breast cancer (stages I-III).
Indication for neoadjuvant or adjuvant chemotherapy containing an anthracycline or a taxane.
Targeted therapies and hormone therapy are permitted according to clinical indication.
3 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Creatine; Placebo
Registered summary
The goal of this clinical trial is to evaluate whether oral creatine supplementation can prevent chemotherapy-related cognitive impairment in patients with early-stage breast cancer undergoing neoadjuvant or adjuvant chemotherapy. The main questions it aims to answer are: * Does creatine supplementation reduce the occurrence and severity of chemotherapy-related cognitive impairment, as measured by patient-reported cognitive function? * Does creatine supplementation preserve objective cognitive performance compared with placebo during and after chemotherapy? Researchers will compare creatine… The full summary is on the listing.
Where, as registered
No US site; Brazil (1).
Not yet recruitingNCT06991426
Effects of CreaSafe® on Kidney, Muscle, and Cardiopulmonary Function in Athletes and COPD Patients
Phase 4
Federal University of São Paulo
About 140 people
Starts Jul 2025 (estimated)
In plain words A Phase 4 study of creatine monohydrate in people of any age, run by Federal University of São Paulo. It plans to enroll about 140 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people of any age; healthy volunteers accepted. Conditions: Copd; Athletes.
resistance-trained athletes middle- and long-distance runners severe and/or very severe COPD
The exclusion criteria are on the listing.
What it tests, as registered
CreaSafe® creatine; Placebo 0.03 g/kg/day
Registered summary
Creatine supplementation (CS) offers numerous health benefits, with no proven side effects reported to date. CS positively impacts all organs and systems of the body. However, there is an ongoing effort among several creatine-producing companies to develop increasingly pure creatine formulations that generate fewer renal metabolites. The full summary is on the listing.
Where, as registered
No US site; Brazil (1).
Not yet recruitingNCT07310043
Creatine and Perioperative Brain Health
No phase
Massachusetts General Hospital
About 120 people
Starts Sep 1, 2026 (estimated)
In plain words A study of creatine monohydrate in people 60 to 85, run by Massachusetts General Hospital. It plans to enroll about 120 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 60 to 85; healthy volunteers accepted. Conditions: Neurocognitive Disorders; Postoperative Delirium.
Patients scheduled for elective surgery under general anesthesia
The exclusion criteria are on the listing.
What it tests, as registered
Creatine monohydrate; Placebo
Registered summary
The overall goal of this study is to evaluate the feasibility of perioperative oral creatine supplementation and to explore its effects on cognitive function and physiological responses to surgery in older adults. Creatine is commonly used to enhance athletic performance, but it can also have positive effects on the brain. Since surgery can alter thinking, memory, and attention patterns in some patients, we will assess whether creatine affects these changes in older adults undergoing surgery.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07756060
Creatine Supplementation in Pediatric Brain Injury
No phase
Spaulding Rehabilitation Hospital
About 46 people
Starts Oct 2026 (estimated)
In plain words A study of creatine monohydrate in people 8 to 25, run by Spaulding Rehabilitation Hospital. It plans to enroll about 46 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 8 to 25. Conditions: Brain Injury; Traumatic Brain Injury; Stroke.
History of subacute moderate-to-severe brain injury resulting in a new functional impairment, as defined by: Glasgow Coma Scale score (GCS) < 13 points
Subacute brain injury is defined to be < 3 months since index injury
The exclusion criteria are on the listing.
What it tests, as registered
Creatine monohydrate; Microcrystalline Cellulose
Registered summary
A study examining the effects of creatine supplementation to improve recovery after brain injury in children and teenagers.
Where, as registered
No sites listed yet.
Not yet recruitingNCT06920667
Effect of a Protein-Creatine-Omega3-Vitamin D Supplement on Glycemic Variability in Mexican Patients With Type 2 Diabetes
No phase
Héctor Iván Saldívar Cerón
About 40 people
Starts Jun 1, 2025 (estimated)
In plain words A study of creatine monohydrate in people 18 to 65, run by Héctor Iván Saldívar Cerón. It plans to enroll about 40 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 65. Conditions: Type 2 Diabetes Mellitus.
Adults aged 18-65 years
Diagnosis of type 2 diabetes mellitus within the past 5 years
HbA1c between 7.0% and 10.0%
BMI between 25 and 40 kg/m²
3 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Protein-Creatine-Omega-3-Vitamin D Supplement; Placebo (Maltodextrin)
Registered summary
This study aims to evaluate the effect of a daily nutritional supplement containing whey protein, creatine, omega-3 fatty acids, and vitamin D on blood sugar fluctuations in adults with recently diagnosed type 2 diabetes. Forty participants will be enrolled in a 12-week, double-blind, randomized clinical trial. Half of the participants will receive the supplement, while the other half will receive a placebo. Blood sugar levels will be monitored using continuous glucose monitoring (CGM) devices placed at five different time points during and after the intervention. The full summary is on the listing.
Where, as registered
No sites listed yet.
Not yet recruitingNCT07593014
Effects of Creatine and Heat Exposure on Exercise Performance and Body Water Distribution
No phase
University of Windsor
About 25 people
Starts Jul 30, 2026 (estimated)
In plain words A study of creatine monohydrate in male participants 18 to 27, run by University of Windsor. It plans to enroll about 25 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists male participants 18 to 27; healthy volunteers accepted. Conditions: Heat Exposure; Exercise Performance; Hydration; Body Fluid Compartments; Creatine Supplementation; Placebo - Control; Plasma Volume.
Healthy biological males between 18 and 27 years of age
Recreationally active males and varsity athletes
Able to safely participate in moderate-intensity exercise and heat exposure
Willing to maintain habitual diet and physical activity throughout the study
3 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Creatine Monohydrate; Maltodextrin (Placebo)
Registered summary
The goal of this clinical trial is to learn whether creatine supplementation changes how the body adapts to repeated exercise in the heat in healthy recreationally active adults and varsity athletes. The study will also examine whether creatine affects fluid balance, blood volume changes and exercise performance. The full summary is on the listing.
Where, as registered
No sites listed yet.
Not yet recruitingNCT06992414
Exploring the Therapeutic Effects of Creatine Supplementation for Long COVID-19
No phase
University of Calgary
About 24 people
Starts Jul 2, 2025 (estimated)
In plain words A study of creatine monohydrate in people 18 to 65, run by University of Calgary. It plans to enroll about 24 people and lists no sites yet.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 65. Conditions: Long COVID Fatigue.
Experiencing symptoms at least 3 months after a COVID-19 diagnosis confirmed by positive polymerase chain reaction (PCR) test
Experiencing post-exertional malaise, as per the DePaul Symptom Questionnaire
The exclusion criteria are on the listing.
What it tests, as registered
Creatine monohydrate
Registered summary
Individuals living with Long COVID often experiencing a degree of undue fatigue after physical or cognitive exertion secondary to the condition, timed post-exertional malaise 9PEM). This trial aims to explore the efficacy of creatine monohydrate in managing PEM
Where, as registered
No sites listed yet.
Not yet recruitingNCT07475676
Effects of Short-term Acute Creatine Supplementation on Power, Speed and Muscular Strengths in Young Football Players
No phase
St. Mary's University, Twickenham
About 20 people
Starts Mar 1, 2026 (estimated)
In plain words A study of creatine monohydrate in people 18 to 45, run by St. Mary's University, Twickenham. It plans to enroll about 20 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 45. Conditions: Performance Enhancement.
Male or female between the age of 18-45
Trained individuals currently playing at a semi-professional (regional) level currently training and competing no more than three times a week
Free of long-term injuries for the last six months
Not supplementing creatine within the last 3 months.
2 more inclusion criteria and the exclusion criteria are on the listing.
What it tests, as registered
Creatine Monohydrate; Placebo
Registered summary
Creatine has been widely studies within the strength and conditioning background and has been seen to show positive effects on performance assess the effects of creatine on sports requiring a range of different fitness components to be successful such as football. Previous research has suggested benefits of creatine supplementation such as increasing PCr (phosphocreatine) stores to aid ATP (adenosine triphosphate) production, increasing muscle water retention resulting in enhanced protein synthesis, reduced muscle damage and anti-inflammation. The full summary is on the listing.
Where, as registered
No US site; United Kingdom (1).
Not yet recruitingNCT07838805
Changing in Plasma Concentration of a New Form of Creatine
No phase
University of Padova
About 9 people
Starts Sep 17, 2026 (estimated)
In plain words A study of creatine monohydrate in people 18 to 35, run by University of Padova. It plans to enroll about 9 people at 1 site, none in the US.
Who it lists and where
Who the trial lists, as registered
Lists people 18 to 35; healthy volunteers accepted. Conditions: Creatine.
Age between 18 and 35 years
No creatine supplementation in the previous 6 months
No history of cardiovascular, metabolic, muscular, or neurological diseases
BMI: 18-30 kg/m²
The exclusion criteria are on the listing.
What it tests, as registered
New Formulation of Creatine (Creamix); Active Comparator: Creatine Monohydrate
Registered summary
Creatine is one of the most popular supplements among athletes. Studies have consistently shown that creatine supplementation increases intramuscular creatine concentrations, improving exercise performance and/or enhancing training adaptations. Research has also indicated that creatine supplementation may improve post-exercise recovery and may help with injury prevention, thermoregulation, rehabilitation, and neuroprotection in cases of concussion and/or spinal cord injury. The full summary is on the listing.
Where, as registered
No US site; Italy (1).
ClinicalTrials.gov lists 68 open registrations for this search, including ones where creatine monohydrate is not a study arm or that are past the 32 we keep. Search them on ClinicalTrials.gov (opens in new tab).